@article {4539,
	title = {Transfusion-related Epstein-Barr virus infection among stem cell transplant recipients: a retrospective cohort study in children.},
	journal = {Transfusion// Transfusion},
	volume = {52},
	year = {2012},
	month = {2012//},
	pages = {2653 - 63},
	address = {United States},
	abstract = {BACKGROUND: Blood safety warrants strict screening measures to minimize the risk of transmitting blood-borne pathogens. However, transfusion-transmitted infections for which testing is not currently performed continue to be a concern. Among these untested agents is Epstein-Barr virus (EBV) which, in the transplant setting, is associated with lymphoproliferative disease, a potentially fatal cancer. The aim of this study was to analyze the incidence of posttransplant EBV infection and its association with administration of blood products in children receiving a hematopoietic stem cell (HSC) graft., STUDY DESIGN AND METHODS: This retrospective cohort study sought to review charts of pediatric recipients of HSC grafts to collect information on the presence of EBV antibodies in the recipients{\textquoteright} pretransplant sera and in HSC donor sera, incidence of posttransplant EBV infection, and patients{\textquoteright} transfusion history. Cumulative incidence of posttransplant EBV infection was estimated by Kaplan-Meier methods according to pretransplant serology. The association between blood products and EBV infection was measured by Cox regression models., RESULTS: The pretransplant EBV seroprevalence was 77.9\% for recipients and 61.8\% for graft donors. Virtually, all recipients received blood products during the peritransplant period. Among seronegative recipients, the 30- and 60-day cumulative incidences of posttransplant EBV infection were 4.6 (95\% confidence interval [CI], 1.2-17.3) and 13.4\% (95\% CI, 5.8\%-29.4\%), respectively. The 60-day cumulative incidence was 8.3\% (95\% CI, 2.2\%-29.4\%) when restricting the analysis to seronegative recipients of cord blood grafts. Importantly, there was a clear positive trend associating EBV infection to transfusion volume., CONCLUSION: This study suggests an association between transfusions and posttransplant EBV infection in HSC transplant recipients.Copyright {\textcopyright} 2012 American Association of Blood Banks.},
	keywords = {*Blood Transfusion/ae [Adverse Effects], *Epstein-Barr Virus Infections/ep [Epidemiology], *Epstein-Barr Virus Infections/tm [Transmission], *Hematopoietic Stem Cell Transplantation/sn [Statistics \& Numerical Data], *Herpesvirus 4, Human/ip [Isolation \& Purification], *Leukemia/th [Therapy], Adolescent, Antibodies, Viral/bl [Blood], Child, Child, Preschool, Epstein-Barr Virus Infections/bl [Blood], Female, Herpesvirus 4, Human/im [Immunology], Humans, Incidence, Kaplan-Meier Estimate, Leukemia/ep [Epidemiology], Male, Prevalence, Retrospective Studies, Risk Factors, Seroepidemiologic Studies},
	isbn = {1537-2995},
	author = {Trottier, Helen and Buteau, Chantal and Robitaille, Nancy and Duval, Michel and Tucci, Marisa and Lacroix, Jacques and Alfieri, Caroline}
}
