@article {4543,
	title = {Transmission of GB virus type C via transfusion in a cohort of HIV-infected patients.},
	journal = {The Journal of infectious diseases// J Infect Dis},
	volume = {205},
	year = {2012},
	month = {2012//},
	pages = {1436 - 42},
	address = {United States},
	abstract = {BACKGROUND: GB virus C (GBV-C) infection is transmitted by blood exposure and associated with lower human immunodeficiency virus (HIV) load and slower HIV disease progression. Few studies describe predictors of acute GBV-C infection following transfusion in HIV-infected patients., METHODS: We used a limited-access database from the National Heart Lung and Blood Institute{\textquoteright}s Viral Activation Transfusion Study, a randomized controlled trial of leukoreduced versus nonleukoreduced transfusions received by HIV-infected, transfusion-naive patients. Blood samples from 489 subjects were tested for GBV-C markers in pretransfusion and posttransfusion samples. We estimated the risk of acquiring GBV-C RNA and predictors of GBV-C acquisition, using pooled logistic regression., RESULTS: GBV-C RNA was detected <120 days following the first transfusion in 22 (7.5\%) of 294 subjects who were GBV-C negative before transfusion. The risk of GBV-C RNA acquisition increased with each unit transfused (odds ratio, 1.09; 95\% confidence interval, 1.06-1.11). Lower baseline HIV load and use of antiretroviral therapy were associated with subsequent GBV-C RNA acquisition, after control for units of blood transfused. Leukoreduced status of transfused units was not associated with GBV-C transmission., CONCLUSIONS: Blood transfusion is associated with a significant risk of GBV-C acquisition among HIV-infected patients. Transmission of GBV-C by blood transfusion was inversely related to HIV load.},
	keywords = {*Blood Transfusion/ae [Adverse Effects], *Flaviviridae Infections/tm [Transmission], *GB virus C/py [Pathogenicity], *HIV Infections/co [Complications], Adult, Antibodies, Viral, CD4 Lymphocyte Count, Female, Flaviviridae Infections/co [Complications], Flaviviridae Infections/vi [Virology], Follow-Up Studies, GB virus C/ip [Isolation \& Purification], HIV Infections/tm [Transmission], HIV Infections/vi [Virology], HIV/ip [Isolation \& Purification], HIV/py [Pathogenicity], Humans, Logistic Models, Male, Prospective Studies, RNA, Viral/ip [Isolation \& Purification], Viral Load, Virus Activation},
	isbn = {1537-6613},
	author = {Vahidnia, Farnaz and Petersen, M and Rutherford, G and Busch, M and Assmann, S and Stapleton, J T and Custer, B}
}
