@article {4582,
	title = {A Cluster of Fatal Tick-borne Encephalitis Virus Infection in Organ Transplant Setting.},
	journal = {The Journal of infectious diseases//J Infect Dis},
	volume = {215},
	year = {2017},
	month = {2017},
	pages = {896 - 901},
	address = {United States},
	abstract = {Background.: Tick-borne encephalitis virus (TBEV) infection has become a major health problem in Europe and is currently a common cause of viral brain infection in many countries. Encephalitis in transplant recipients, althrough rare, is becoming a recognized complication. Our study provides the first description of transmission of TBEV through transplantation of solid organs., Methods.: Three patients who received solid organ transplants from a single donor (2 received kidney, and 1 received liver) developed encephalitis 17-49 days after transplantation and subsequently died. Blood and autopsy tissue samples were tested by next-generation sequencing (NGS) and reverse transcription polymerase chain reaction (RT-PCR)., Results.: All 3 recipients were first analyzed in autopsy brain tissue samples and/or cerebrospinal fluid by NGS, which yielded 24-52 million sequences per sample and 9-988 matched TBEV sequences in each patient. The presence of TBEV was confirmed by RT-PCR in all recipients and in the donor, and direct sequencing of amplification products corroborated the presence of the same viral strain., Conclusions.: We demonstrated transmission of TBEV by transplantation of solid organs. In such a setting, TBEV infection may be fatal, probably due to pharmacological immunosuppression. Organ donors should be screened for TBEV when coming from or visiting endemic areas.},
	isbn = {1537-66130022-1899},
	author = {Lipowski, Dariusz and Popiel, Marta and Perlejewski, Karol and Nakamura, Shota and Bukowska-Osko, Iwona and Rzadkiewicz, Ewa and Dzieciatkowski, Tomasz and Milecka, Anna and Wenski, Wojciech and Ciszek, Michal and Debska-Slizien, Alicja and Ignacak, Ewa and Cortes, Kamila Caraballo and Pawelczyk, Agnieszka and Horban, Andrzej and Radkowski, Marek and Laskus, Tomasz}
}
