@article {4589,
	title = {Outcome of Transplantation Using Organs From Donors Infected or Colonized With Carbapenem-Resistant Gram-Negative Bacteria.},
	journal = {American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons//Am J Transplant},
	volume = {15},
	year = {2015},
	month = {2015},
	pages = {2674 - 82},
	address = {United States},
	abstract = {Donor-derived infections due to multidrug-resistant bacteria are a growing problem in solid organ transplantation, and optimal management options are not clear. In a 2-year period, 30/214 (14\%) recipients received an organ from 18/170 (10.5\%) deceased donors with infection or colonization caused by a carbapenem-resistant gram-negative bacteria that was unknown at the time of transplantation. Among them, 14/30 recipients (47\%) received a transplant from a donor with bacteremia or with infection/colonization of the transplanted organ and were considered at high risk of donor-derived infection transmission. The remaining 16/30 (53\%) recipients received an organ from a nonbacteremic donor with colonization of a nontransplanted organ and were considered at low risk of infection transmission. Proven transmission occurred in 4 of the 14 high-risk recipients because donor infection was either not recognized, underestimated, or not communicated. These recipients received late, short or inappropriate posttransplant antibiotic therapy. Transmission did not occur in high-risk recipients who received appropriate and prompt antibiotic therapy for at least 7 days. The safe use of organs from donors with multidrug-resistant bacteria requires intra- and inter-institutional communication to allow appropriate management and prompt treatment of recipients in order to avoid transmission of infection. , {\textcopyright} Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.},
	keywords = {*Carbapenems, *Drug Resistance, Multiple, Bacterial, *Gram-Negative Bacterial Infections/tm [Transmission], *Organ Transplantation/ae [Adverse Effects], *Tissue Donors, Adult, Aged, Female, Gram-Negative Bacterial Infections/dt [Drug Therapy], Gram-Negative Bacterial Infections/pc [Prevention \& Control], Humans, Infant, Male, Middle Aged, Retrospective Studies, Treatment Outcome},
	isbn = {1600-61431600-6135},
	author = {Mularoni, A and Bertani, A and Vizzini, G and Gona, F and Campanella, M and Spada, M and Gruttadauria, S and Vitulo, P and Conaldi, P and Luca, A and Gridelli, B and Grossi, P}
}
