@article {4614,
	title = {RH genotyping in a sickle cell disease patient contributing to hematopoietic stem cell transplantation donor selection and management},
	volume = {116},
	year = {2010},
	pages = {6},
	abstract = {African individuals harbor molecular RH variants, which permit alloantibody formation to high-prevalence Rh antigens after transfusions. Genotyping identifies such RH variants, which are often missed by serologic blood group typing. Comprehensive molecular blood group analysis using 3 genotyping platforms, nucleotide sequencing, and serologic evaluation was performed on a 7-year-old African male with sickle cell disease who developed an "e-like" antibody shortly after initiating monthly red blood cell (RBC) transfusions for silent stroke. Genotyping of the RH variant predicted a severe shortage of compatible RBCs for long-term transfusion support, which contributed to the decision for hematopoetic stem cell transplantation. RH genotyping confirmed the RH variant in the human leukocyte antigen-matched sibling donor. The patient{\textquoteright}s (C)ce(s) type 1 haplotype occurs in up to 11\% of African American sickle cell disease patients; however, haplotype-matched RBCs were serologically incompatible. This case documents that blood unit selection should be based on genotype rather than one matching haplotype.},
	doi = {10.1182/blood-2010-04-279372},
	author = {Fasano, RM and Monaco, A and Meier, ER and Pary, P and Lee-Stroka, AH and Otridge, J and Klein, HG and Marincola, FM and Kamani, NR and Luban, NL and Stroncek, D and Flegel, WA}
}
