@article {4671,
	title = {Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report.},
	volume = {57},
	year = {2017},
	month = {Feb},
	abstract = {BACKGROUND:

Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion-transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma.
STUDY DESIGN AND METHODS:

A 61-year-old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette-Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored.
RESULTS:

Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient{\textquoteright}s serum sample.
CONCLUSION:

Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.},
	doi = {10.1111/trf.13876},
	author = {Riveiro-Barciela, M and Sauleda, S and Quer, J and Salvador, F and Gregori, J and Pir{\'o}n, M and Rodr{\'\i}guez-Fr{\'\i}as, F and Buti, M}
}
