@article {4699,
	title = {Rapid screening for malignancy in organ donors: 15-year experience with the Verona "Alert" protocol and review of the literature},
	volume = {31},
	year = {Submitted},
	month = {Sep},
	abstract = {BACKGROUND:

Prevention of transmission of malignancy from donors to recipients is an aim of donor assessment. We report the most stringent interpretation of the Italian National Guidelines.
METHODS:

A two-step ALERT process was used: ALERT1 consisting of clinical, radiological, and laboratory tests; ALERT2, consisting of intraoperative assessment in suspicious lesions.
RESULTS:

Four hundred of 506 potential deceased donors entered the ALERT system. Forty-one of 400 (10\%) donors were excluded due to unacceptable risk of transmission. Of the remaining 359 193 required histopathology, which excluded malignancy or determined acceptable risk in 161/193 (83\%). Thirty-five malignancies were identified: 19 (54\%) at ALERT1, four (11\%) at ALERT2, nine (26\%) picked up at ALERT1 and confirmed by ALERT2. Three (9\%) were missed by ALERT and diagnosed at postmortem examination. Prostate (n=12\%, 34\%) and renal cell (n=7\%, 20\%) were the most frequent carcinomas. The majority (92\%) of prostate adenocarcinomas were of low risk and donation proceeded compared to 43\% of renal carcinomas. Four renal carcinomas, two breast carcinomas, and a single case of nine different malignancies excluded donation. Positive ALERT donors had statistically more malignant reports than negative ALERT donors (P=<.05).
CONCLUSION:

Histopathology is an essential component of the multidisciplinary assessment of donors.},
	doi = {10.1111/ctr.13045},
	author = {Eccher, A and Cima, L and Ciangherotti, A and Montin, U and Violi, P and Carraro, A and Tedeschi, U and Nacchia, F and Fior, F and Rostand, M and Boschiero, L and D{\textquoteright}Errico, A and Scarpa, A and Casartelli-Liviero, M and Ferrari, G and Rodini, V and Tomaselli, E and Zampicinini, L and Vanzo, F and Bovo, C and Feltrin, G and Neil, D and Brunelli, M}
}
