@article {4703,
	title = {Liver Transplantation From Donors With a History of Malignancy: A Single-Center Experience},
	volume = {3},
	year = {2017},
	month = {Oct},
	pages = {e224},
	abstract = {Background:

The demand for transplantable organs exceeds donor organ supply. Transplantation of organs from donors with a history of malignancy remains controversial and the transmission of cancer in liver transplant recipients has not been sufficiently examined.
Methods:

From 2002 until 2017, 83 livers from donors with a history of malignancy were transplanted at the University Hospital Essen, Germany. Donor and recipient data, type of malignancy, tumor-free interval at organ procurement, and follow-up data were analyzed.
Results:

Nine different tumor sites (central nervous system [n = 27], genitourinary [n = 24], breast [n = 10], skin [n = 8], colorectal [n = 5], lung [n = 3], hemato-oncological [n = 3], thyroid [n = 2], and larynx [n = 1]) were detected in 83 donors. The majority (58\%) of donors had tumor-free intervals of less than 5 years versus 19\% of 6 to 10 years versus 23\% over 10 years. The risk of tumor transmission from donors was assessed as low in 44 (53\%), intermediate in 28 (34\%), and high in 11 (13\%) cases. During median follow-up of 19.9 (0-155) months, none of the recipients developed donor-transmitted malignancy.
Conclusions:

Liver transplantation with organs from donors with a medical history of malignancy is feasible, and the risk of donor-transmitted malignancy appears to be low in this single-center analysis. A careful selection of donors remains mandatory and can expand the donor pool.},
	doi = {10.1097/TXD.0000000000000738},
	author = {Benk{\"o}, T and Hoyer, DP and Saner, FH and Treckmann, JW and Paul, A and Radunz, S}
}
