@article {4763,
	title = {Transfusion-Transmitted Dengue and Associated Clinical Symptoms During the 2012 Epidemic in Brazil},
	volume = {213},
	year = {2016},
	month = {Mar},
	pages = {694},
	abstract = {BACKGROUND:

A linked donor-recipient study was conducted during epidemics in 2 cities in Brazil to investigate transfusion-transmitted (TT) dengue virus (DENV) by DENV RNA-positive donations.
METHODS:

During February-June 2012, samples were collected from donors and recipients and retrospectively tested for DENV RNA by transcription-mediated amplification. Recipient chart review, using a case (DENV positive)-control (DENV negative and not known to be exposed) design, was conducted to assess symptoms.
RESULTS:

Of 39 134 recruited blood donors, DENV-4 viremia was confirmed in 0.51\% of donations from subjects in Rio de Janeiro and 0.80\% of subjects in Recife. Overall, 42 DENV RNA-positive units were transfused into 35 recipients. Of these, 16 RNA-positive units transfused into 16 susceptible recipients were identified as informative: 5 cases were considered probable TT cases, 1 possible TT case, and 10 nontransmissions. The TT rate was 37.5\% (95\% confidence interval [CI], 15.2\%-64.6\%), significantly higher than the viremia rate of 0.93\% (95\% CI, .11\%-3.34\%) in nonexposed recipients (P < .0001). Chart review did not find significant differences between cases and controls in symptoms or mortality.
CONCLUSIONS:

During a large epidemic of DENV-4 infection in Brazil, >0.5\% of donations were RNA positive, and approximately one third of components resulted in TT. However, no significant clinical differences were evident between RNA-positive and RNA-negative recipients.},
	doi = {10.1093/infdis/jiv326},
	author = {Sabino, EC and Loureiro, P and Lopes, ME and Capuani, L and McClure, C and Chowdhury, D and Di-Lorenzo-Oliveira, C and Oliveira, LC and Linnen, JM and Lee, TH and Gon{\c c}alez, T and Brambilla, D and Kleinman, S and Busch, MP and Custer, B and International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III}
}
