@article {4824,
	title = {Safety and efficacy of cryopreserved platelets in bleeding patients with thrombocytopenia},
	volume = {58},
	year = {2018},
	month = {Sep},
	pages = {9},
	abstract = {BACKGROUND:  The short dating period of room temperature-stored platelets (PLTs; 5-7 days) limits their availability at far-forward combat facilities and at remote civilian sites in the United States. PLT cryopreservation in 6\% DMSO and storage for up to 2 years may improve timely availability for bleeding patients. STUDY DESIGN AND METHODS:  A dose escalation trial of DMSO-cryopreserved PLTs (CPPs) compared to standard liquid-stored PLTs (LSPs) was performed in bleeding patients with thrombocytopenia. Within each of four cohorts, six patients received escalating doses of CPP (0.5 unit, 1 unit, and sequential transfusions of 2 and 3 units) and one received a LSP transfusion. Patients were monitored for adverse events (AEs), coagulation markers, PLT responses, and hemostatic efficacy. RESULTS:  Patients with a World Health Organization bleeding score of 2 or more received from 0.5 to 3 units of CPP (n = 24) or 1 unit of LSP (n = 4). There were no related thrombotic or other serious AEs experienced. Mild transfusion-related AEs of chills and fever (n = 1), transient increased respiratory rate (n = 1), DMSO-related skin odor (n = 2), and headache (n = 1) were observed after CPP transfusion. Among CPP recipients 14 of 24 (58\%) had improved bleeding scores, including three of seven (43\%) patients who had intracerebral bleeding. CPP posttransfusion PLT increments were significantly less than those of LSPs; however, days to next transfusion were the same. After transfusion, the CPP recipients had improvements in some variables of thrombin generation tests and thromboelastography. CONCLUSION:  Cryopreserved PLT transfusions appear to be safe and effective when given to bleeding patients with thrombocytopenia.},
	author = {Slichter, SJ and Dumont, LJ and Cancelas, JA and Jones, M and Gernsheimer, TB and Szczepiorkowski, ZM and Dunbar, NM and Prakash, G and Medlin, S and Rugg, N and Kinne, B and Macdonald, VW and Housler, G and Valiyaveettil, M and Hmel, P and Ransom, JH}
}
