@article {4833,
	title = {Immunosuppression and lung cancer of donor origin after bilateral lung transplantation},
	volume = {76},
	year = {2012},
	month = {Apr},
	pages = {8},
	abstract = {Analysis of databases from transplant recipients revealed a 3-5 fold higher risk to develop de novo malignancies under continued immunosuppression. The underlying mechanisms are poorly understood. Here we describe a patient who received a bilateral lung transplantation for end-stage {\textquoteright}usual interstitial pneumonia{\textquoteright} (UIP) resulting in idiopathic lung fibrosis. The recipient presented with a non-small cell lung carcinoma (NSCLC) in the donor lung 7 months later. Molecular and immunological typing of the tumor revealed a cancer of donor origin with a prominent intratumoral immune cell infiltrate without detectable effector function. This is a unique case of de novo outgrowth of a NSCLC of donor origin under continued immunosuppression, supporting the concept of tumor immunosurveillance in vivo.},
	author = {von Boehmer, L and Draenert, A and Jungraithmayr, W and Inci, I and Niklaus, S and Boehler, A and Hofer, M and Stahel, R and Soltermann, A and van den Broek, M and Weder, W and Knuth, A}
}
