@article {4894,
	title = {Clinical outcomes after peripheral blood stem cell donation by related donors: a Dutch single-center cohort study},
	volume = {53},
	year = {2013},
	month = {Jan},
	pages = {96},
	abstract = {Background: Relatives donating peripheral blood stem cells (PBSCs) may be accepted for donation on less strict criteria than unrelated donors. We evaluated the occurrence of adverse events during procedure and follow-up, with a special focus on donors who would have been deferred as unrelated donors.

Study design and methods: All 268 related PBSC donors at our center (1996-2006) were included. Data were retrospectively collected from medical reports and standard follow-up. Health questionnaires were sent from 2007. Medical outcomes of donors, deferrable or eligible according to international criteria for unrelated donation, were compared.

Results: Forty donors (15\%) would have been deferred for unrelated donation. Short-term adverse events occurred in 2\% of procedures. Questionnaires were returned by 162 (60\%) donors on average 7.5 years after donation, bringing total person-years of follow-up to 1278 (177 in deferrable donors). Nine malignancies and 14 cardiovascular events were reported. The incidence rate of cardiovascular events in eligible donors was 6.5 (95\% confidence interval [CI], 2.5-12.3) per 1000 person-years compared to 44.9 (95\% CI, 17.4-85.2) in deferrable donors; incidence rates of malignancies were 4.6 (1.4-9.6) and 24.0 (6.0-53.9) per 1000 person-years, respectively, in eligible and deferrable donors. All incidence rates were within the range of age- and sex-matched general population. No autoimmune disorders were reported.

Conclusion: In both the eligible and the deferrable related donors treated with granulocyte-colony-stimulating factor there are few short-term and long-term problems. The occurrence of post-PBSC cardiovascular events and malignant disease in related donors appears to be within the range of the general population.},
	author = {Wiersum-Osselton, JC and van Walraven, SM and Bank, I and Mari{\"e}tte Lenselink, A and Fibbe, WE and van der Bom, JG and Brand, A}
}
