@article {5123,
	title = {Donor-to-recipient transmission and reactivation in a kidney transplant recipient of an inherited chromosomally integrated HHV-6A: Evidence and outcomes},
	volume = {20},
	year = {2020},
	month = {Dec},
	abstract = {<p>Human herpesvirus (HHV)-6A can be inherited and chromosomally integrated (iciHHV-6A), and donor-to-recipient transmission has been reported in solid organ transplant. However, when HHV-6A reactivation happens after transplant, the source of HHV-6A is often not evident and its pathogenicity remains unclear. Here, we present an exhaustive case of donor-to-recipient transmission and reactivation of iciHHV-6A through kidney transplant. The absence of HHV-6A genome from the nails of the recipient excluded a recipient-related iciHHV-6A. Viral loads \&gt; 7 log10 copies/106 cells in donor blood samples and similarities of U38, U39, U69, and U100 viral genes between donor, recipient, and previously published iciHHV-6A strains are proof of donor-related transmission. Detection of noncoding HHV-6 snc-RNA14 using fluorescence in situ hybridization analysis and immunofluorescence staining of HHV-6A gp82/gp105 late proteins on kidney biopsies showed evidence of reactivation in the transplanted kidney. Because HHV-6A reactivation can be life threatening in immunocompromised patients, we provide several tools to help during the complete screening and diagnosis.</p>},
	doi = {10.1111/ajt.16067},
	author = {Petit, V and Bonnafous, P and Fages, V and Gautheret-Dejean, A and Engelmann, I and Baras, A and Hober, D and G{\'e}rard, R and Gibier, JB and Leteurtre, E and Glowacki, F and Moulonguet, F and Decaestecker, A and Prov{\^o}t, F and Chamley, P and Prusty, BK and Maanaoui, M and Faure, E and Hazzan, M}
}
