@article {90,
	title = {Comparison between once a day vs twice a day G-CSF for mobilization of peripheral blood progenitor cells (PBPC) in normal donors for allogeneic PBPC transplantation},
	journal = {Bone Marrow Transplantation},
	volume = {22},
	year = {1998},
	note = {HPC},
	pages = {39 - 45},
	abstract = {Despite the wide use of G-CSF for mobilization of PBPC the best dose and schedule of G-CSF has not been definitively established. In this study we have compared three different schedules of G-CSF for mobilization of PBPC in normal donors including a single daily dose of 10 microg/kg/day for 5 days (21 donors) and doses of 6 (21 donors) or 8 microg/kg/12 h (6 donors) for 5 days. We demonstrate that G-CSF at doses of 6 and 8 microg/kg/12 h mobilizes significantly more CD34+ cells/ml of blood (83.3 +/- 6.7 and 121 +/- 6.9, respectively) than 10 microg/kg/day (71.6 +/- 6.5). Mobilization with 6 or 8 microg/kg/12 h of G-CSF was also associated with collection of significantly more CD34+ cells in comparison with 10 microg/kg/24 h (2.24 +/- 1.2 and 2.46 +/- 1.22 vs 1.15 +/- 0.8 CD34+ cells/kg of donor/blood volume). PBPC collection was associated with a significant decrease in platelet count which was not significantly different between the three groups. Ten days after the last PBPC collection platelet counts were within normal limits while there was a decrease in WBC and ANC. We conclude that G-CSF administered every 12 h at doses of 6 microg/kg provides better CD34+ cell yield than 10 microg/kg once a day in normal donors which may translate into a decrease in the number of aphereses required to obtain enough numbers of CD34+ cells for allogeneic PBPC transplant.},
	keywords = {*Granulocyte Colony-Stimulating Factor / ad [Administration \& Dosage], *Hematopoietic Stem Cell Mobilization / mt [Methods], *Hematopoietic Stem Cell Transplantation, Adolescent, Adult, Aged, Blood Cell Count / de [Drug Effects], Blood Component Removal / ae [Adverse Effects], Child, Drug Administration Schedule, Female, Hematopoietic Stem Cell Mobilization / ae [Adverse Effects], Humans, Male, Middle Aged, Transplantation, Homologous},
	author = {Arbona,C. and Prosper,F. and Benet,I. and Mena,F. and Solano,C. and Garcia-Conde,J.}
}
