@article {111,
	title = {The relationship of graft survival and herpes simplex virus latency in recipient corneal buttons},
	journal = {Clin Ophthalmol},
	volume = {1},
	year = {2007},
	note = {Aydemir, Orhan Turkcuoglu, Peykan Bulut, Yasemin Kalkan, Ahmet New Zealand Clinical ophthalmology (Auckland, N.Z.) Clin Ophthalmol. 2007 Jun;1(2):127-31.},
	month = {Jun},
	pages = {127 - 31},
	edition = {39234},
	abstract = {PURPOSE: To demonstrate relationship between herpes simplex virus (HSV) corneal latency and graft survival. METHODS: Prospective case control study. 28 recipient corneal buttons and donor cornea-scleral remnants were examined for HSV DNA with polymerase chain reaction (PCR). None of the recipient had a history of HSV infection. Serum samples of graft recipients were analyzed for the presence of anti-HSV IgG and IgM with enzyme-linked immunosorbent assay technique. All corneas were free of stromal scarring or epithelial defect before sampling and had an endothelial cell density of >2000 cells/mm(2). RESULTS: In twenty three patients (82\%) anti-HSV IgG was detected in serum. In none of the recipients anti-HSV IgM was positive. HSV DNA was positive in six out of twenty eight (21\%) of the recipient corneal buttons and none of the donor cornea-scleral remnants. In eighteen-months follow-up period three out of six (50\%) HSV DNA positive and one out of twenty-two (4.5\%) HSV DNA negative patients experienced late endothelial failure that was statistically significantly different (p = 0.022). CONCLUSION: Even without a history of HSV keratitis, presence of latent HSV virus in recipient cornea is an important risk factor for subsequent graft survival.},
	issn = {1177-5467 (Print)},
	url = {internal-pdf://Aydemir - HSV-4185884929/Aydemir - HSV.pdf},
	author = {Aydemir,O. and Turkcuoglu,P. and Bulut,Y. and Kalkan,A.}
}
