@article {416,
	title = {Secondary malignancies after marrow transplantation},
	journal = {Exp Hematol},
	volume = {12},
	year = {1984},
	note = {0301-472X (Print) Journal Article},
	month = {Sep},
	pages = {660 - 6},
	abstract = {Secondary malignancies after marrow transplantation have been observed in 20 patients: 19 patients underwent marrow transplantation for the treatment of a hemopoietic malignancy and one for aplastic anemia. All but three were given total body irradiation at doses of 8.0-15.75 Gy as part of the conditioning regimen. Secondary malignancies were composed of three groups: (a) Six patients had recurrence of leukemia (three acute lymphoblastic, two acute myeloblastic, and one chronic myelocytic) in cells of donor origin 62-1074 days after grafting. (b) Eight patients developed lymphoproliferative disorders (four of immunoblastic sarcoma type, one lymphoblastic, one follicular center cell, and one Hodgkin{\textquoteright}s lymphoma and one acute lymphoblastic leukemia) 54-730 days after grafting. In four of seven patients with appropriate studies these tumors were of donor-cell origin and in three of four tested the cells contained Epstein-Barr virus genome or expressed viral antigens. (c) Six patients developed solid tumors (two glioblastoma multiforme, two adenocarcinomas, one squamous cell carcinoma, and one sarcoma) 347-1875 days after grafting. All but two patients (one with glioblastoma and one with squamous cell carcinoma) have died. These data suggest that patients undergoing marrow transplantation for a hemopoietic malignancy may be at risk of developing secondary malignancies. The etiology appears to be multifactorial, including irradiation, immunosuppression, Epstein-Barr virus infections, and other factors.},
	keywords = {*Bone Marrow Transplantation, Adolescent, Adult, Child, Child, Preschool, Chimera, Female, Follow-Up Studies, Graft vs Host Disease / prevention \& control, Humans, Immunosuppression, Leukemia / *therapy, Male, Middle Aged, Neoplasms / *etiology, Research Support, U.S. Gov{\textquoteright}t, P.H.S., Transplantation, Isogeneic / *adverse effects},
	author = {Deeg,H. J. and Sanders,J. and Martin,P. and Fefer,A. and Neiman,P. and Singer,J. and Storb,R. and Thomas,E. D.}
}
