@article {579,
	title = {Donor morbidity after living donation for liver transplantation},
	journal = {Gastroenterology},
	volume = {135},
	year = {2008},
	note = {Ghobrial, Rafik M Freise, Chris E Trotter, James F Tong, Lan Ojo, Akinlolu O Fair, Jeffrey H Fisher, Robert A Emond, Jean C Koffron, Alan J Pruett, Timothy L Olthoff, Kim M A2ALL Study Group U01 DK062494-08/DK/NIDDK NIH HHS/United States U01-DK62444/DK/NIDDK NIH HHS/United States U01-DK62467/DK/NIDDK NIH HHS/United States U01-DK62483/DK/NIDDK NIH HHS/United States U01-DK62484/DK/NIDDK NIH HHS/United States U01-DK62494/DK/NIDDK NIH HHS/United States U01-DK62496/DK/NIDDK NIH HHS/United States U01-DK62498/DK/NIDDK NIH HHS/United States U01-DK62505/DK/NIDDK NIH HHS/United States U01-DK62531/DK/NIDDK NIH HHS/United States U01-DK62536/DK/NIDDK NIH HHS/United States Multicenter Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov{\textquoteright}t Research Support, U.S. Gov{\textquoteright}t, P.H.S. United States Gastroenterology Gastroenterology. 2008 Aug;135(2):468-76. Epub 2008 Apr 22.},
	month = {Aug},
	pages = {468 - 76},
	edition = {39597},
	abstract = {BACKGROUND \& AIMS: Reports of complications among adult right hepatic lobe donors have been limited to single centers. The rate and severity of complications in living donors were investigated in the 9-center Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). METHODS: A retrospective observational study design was used. Participants included all potential living donors evaluated between 1998 and 2003. Complication severity was graded using the Clavien scoring system. RESULTS: Of 405 donors accepted for donation, 393 underwent donation, and 12 procedures were aborted. There were 245 donors (62\%) who did not experience complications; 82 (21\%) had 1 complication, and 66 (17\%) had 2 or more. Complications were scored as grade 1 (minor; n = 106, 27\%), grade 2 (potentially life threatening; n = 103, 26\%), grade 3 (life threatening; n = 8, 2\%), and grade 4 (leading to death; n = 3, 0.8\%). Common complications included biliary leaks beyond postoperative day 7 (n = 36, 9\%), bacterial infections (n = 49, 12\%), incisional hernia (n = 22, 6\%), pleural effusion requiring intervention (n = 21, 5\%), neuropraxia (n = 16, 4\%), reexploration (n = 12, 3\%), wound infections (n = 12, 3\%), and intraabdominal abscess (n = 9, 2\%). Two donors developed portal vein thrombosis, and 1 had inferior vena caval thrombosis. Fifty-one (13\%) donors required hospital readmission, and 14 (4\%) required 2 to 5 readmissions. CONCLUSIONS: Adult living liver donation was associated with significant donor complications. Although most complications were of low-grade severity, a significant proportion were severe or life threatening. Quantification of complication risk may improve the informed consent process, perioperative planning, and donor care.},
	keywords = {*Liver Transplantation / statistics \& numerical data, *Living Donors / statistics \& numerical data, Adult, Female, Hepatectomy / *adverse effects / mortality, Humans, Informed Consent, Intraoperative Complications / epidemiology, Length of Stay, Logistic Models, Male, Middle Aged, Odds Ratio, Patient Education as Topic, Patient Readmission, Postoperative Complications / epidemiology, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, United States},
	issn = {1528-0012 (Electronic) 0016-5085 (Linking)},
	doi = {S0016-5085(08)00670-7 [pii] 10.1053/j.gastro.2008.04.018},
	author = {Ghobrial,R. M. and Freise,C. E. and Trotter,J. F. and Tong,L. and Ojo,A. O. and Fair,J. H. and Fisher,R. A. and Emond,J. C. and Koffron,A. J. and Pruett,T. L. and Olthoff,K. M.}
}
