@article {637,
	title = {Pilot study of early corticosteroid elimination after pancreas transplantation},
	journal = {Transplant Proc},
	volume = {37},
	year = {2005},
	note = {0041-1345 (Print) Clinical Trial Journal Article},
	month = {Mar},
	pages = {1287 - 8},
	abstract = {Early corticosteroid withdrawal has recently been shown to be possible in recipients of simultaneous pancreas kidney transplants; however, its feasibility in solitary pancreas recipients has not been documented. In the present study, we provide evidence that early withdrawal can be achieved in pancreas as well as pancreas-kidney recipients. METHODS: Twenty type I diabetics underwent 13 pancreas-kidney transplants and 7 pancreas-only transplants with early withdrawal (methylprednisone 6-day taper). Additional immunosuppression consisted of tacrolimus, mycophenolate mofetil, and thymoglobulin induction (five doses). RESULTS: Transplants included 13 pancreas-kidney, 6 pancreas after kidney transplant, and 1 pancreas after islet transplant. Overall mean follow-up was 7.3 months. One episode of pancreas transplant rejection after pancreas-only transplant was detected on protocol biopsy without biochemical abnormalities. One renal allograft rejection occurred 65 days posttransplant in a pancreas-kidney recipient and was graded as a Banff IA rejection. A single pancreas graft loss occurred due to thrombosis 6 days after pancreas-kidney transplantation. CONCLUSIONS: These results indicate that relatively short thymoglobulin induction (five doses) with tacrolimus and mycophenolate mofetil can allow early withdrawal in both pancreas-kidney and pancreas-only transplant recipients.},
	keywords = {Adrenal Cortex Hormones / *administration \& dosage / adverse, Adult, Continental Population Groups, Diabetes Mellitus, Type 1 / *surgery, Diabetic Nephropathies / immunology / surgery, Drug Administration Schedule, effects / therapeutic use, Female, Graft Rejection / epidemiology, Humans, Immunosuppressive Agents / therapeutic use, Kidney Failure, Chronic / surgery, Kidney Transplantation / physiology, Male, Ohio, Pancreas Transplantation / immunology / *physiology, Pilot Projects},
	author = {Hanaway,M. J. and Roy-Chaudhury,P. and Buell,J. F. and Thomas,M. and Munda,R. and Alloway,R. R. and Ellison,V. and Rudich,S. M. and Fisher,L. and Woodle,E. S.}
}
