@article {650,
	title = {Infectious disease risk factors of corneal graft donors},
	journal = {Archives of ophthalmology},
	volume = {126},
	year = {2008},
	note = {Hassan, Sohela S Wilhelmus, Kirk R Dahl, Patricia Davis, Gregory C Roberts, Russell T Ross, Kevin W Varnum, Bruce H Medical Review Subcommittee of the Eye Bank Association of America EY016631/EY/NEI NIH HHS/ F32 EY016631-02/EY/NEI NIH HHS/ T32 EY007001-28/EY/NEI NIH HHS/ Arch Ophthalmol. 2008 Feb;126(2):235-9.},
	month = {Feb},
	pages = {235 - 9},
	type = {Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov{\textquoteright}t},
	edition = {39491},
	abstract = {OBJECTIVE: To determine how donor health status affects the risk of infection after corneal transplant. METHODS: An adverse reaction surveillance registry was used to conduct a matched case-control study among transplanted donor corneas from January 1, 1994, to December 31, 2003. Cases comprised 162 reports of endophthalmitis after penetrating keratoplasty including 121 with microbial recovery, of which 59 had concordant donor and recipient microbial isolates. Two controls were matched to each case by surgery date. Conditional logistic regression estimated adjusted odds ratios with 95\% confidence intervals according to the premortem status of decedent donors. RESULTS: Postkeratoplasty endophthalmitis was associated with recent hospitalization (odds ratio, 2.84; 95\% confidence interval, 1.61-4.98) and fatal cancer (odds ratio, 2.46; 95\% confidence interval, 1.53-3.97) among donors. Endophthalmitis appeared more likely with tissues transplanted longer than 5 days after donation (odds ratio, 1.55; 95\% confidence interval, 1.02-2.35). The prevalence of concordant microbial isolates from donors and recipients was greater among fungal endophthalmitis than among bacterial endophthalmitis (P < .001). CONCLUSIONS: Corneal grafts with eye tissue obtained from donors dying in the hospital or with cancer may have an increased risk of postsurgical endophthalmitis, possibly due to donor-to-host microbial transmission. Together with donor screening and processing, improvements in microbiological control may reduce infection associated with corneal transplant.},
	keywords = {*Cornea, *Disease Transmission, Infectious, *Postoperative Complications, *Tissue Donors, Adult, Aged, Case-Control Studies, Cause of Death, Confidence Intervals, Endophthalmitis / microbiology / *transmission, Eye Banks / statistics \& numerical data, Eye Infections / microbiology / *transmission, Health Status, Humans, Keratoplasty, Penetrating / *adverse effects, Middle Aged, Odds Ratio, Population Surveillance, Registries / statistics \& numerical data, Risk Factors, United States},
	issn = {0003-9950 (Print) 0003-9950 (Linking)},
	doi = {10.1001/archophthalmol.2007.45},
	author = {Hassan,S. S. and Wilhelmus,K. R. and Dahl,P. and Davis,G. C. and Roberts,R. T. and Ross,K. W. and Varnum,B. H.}
}
