@article {705,
	title = {Cryptococcus neoformans infection in organ transplant recipients: variables influencing clinical characteristics and outcome},
	journal = {Emerg Infect Dis},
	volume = {7},
	year = {2001},
	note = {Husain, S Wagener, M M Singh, N Review United States Emerging infectious diseases Emerg Infect Dis. 2001 May-Jun;7(3):375-81.},
	month = {May-Jun},
	pages = {375 - 81},
	edition = {37043},
	abstract = {Unique clinical characteristics and other variables influencing the outcome of Cryptococcus neoformans infection in organ transplant recipients have not been well defined. From a review of published reports, we found that C. neoformans infection was documented in 2.8\% of organ transplant recipients (overall death rate 42\%). The type of primary immunosuppressive agent used in transplantation influenced the predominant clinical manifestation of cryptococcosis. Patients receiving tacrolimus were significantly less likely to have central nervous system involvement (78\% versus 11\%, p =0.001) and more likely to have skin, soft-tissue, and osteoarticular involvement (66\% versus 21\%, p = 0.006) than patients receiving nontacrolimus- based immunosuppression. Renal failure at admission was the only independently significant predictor of death in these patients (odds ratio 16.4, 95\% CI 1.9-143, p = 0.004). Hypotheses based on these data may elucidate the pathogenesis and may ultimately guide the management of C. neoformans infection in organ transplant recipients.},
	keywords = {Adolescent, Adult, Aged, Child, Cryptococcosis / complications / *epidemiology / mortality, Female, Humans, Male, Middle Aged, Organ Transplantation / *adverse effects, Time Factors},
	issn = {1080-6040 (Print) 1080-6040 (Linking)},
	author = {Husain,S. and Wagener,M. M. and Singh,N.}
}
