@article {984,
	title = {Effects of granulocyte-colony-stimulating factor on potential normal granulocyte donors},
	journal = {Transfusion},
	volume = {39},
	year = {1999},
	note = {McCullough, J Clay, M Herr, G Smith, J Stroncek, D Clinical Trial United states Transfusion Transfusion. 1999 Oct;39(10):1136-40.},
	month = {Oct},
	pages = {1136 - 40},
	edition = {36459},
	abstract = {BACKGROUND: The use of granulocyte-colony-stimulating factor (G-CSF) to increase the granulocyte count and the yield from leukapheresis in normal donors is leading to renewed interest in granulocyte transfusion. Therefore, it is important to understand the side effects of G-CSF. STUDY DESIGN AND METHODS: We studied the effect of G-CSF on peripheral blood counts and recorded the side effects experienced 24 hours after an injection of G-CSF in normal subjects donating peripheral blood progenitor cells for research. RESULTS: Following administration of G-CSF to 261 donors, the neutrophil count increased to 20.6 to 24.5 x 10(9) per microL depending on the dose of G-CSF. This represented a 6.2 to 7.4-fold increase over the neutrophil count before G-CSF administration. Of all donors, 69 percent experienced one or more side effects. The most common effects were: muscle and bone pain, headache, fatigue, and nausea. There was a relationship between the dose of G-CSF and the likelihood of experiencing a side effect. Most side effects were mild, but about 75 percent of donors took analgesics because of them. CONCLUSIONS: In a granulocyte donation program involving G-CSF stimulation, about two-thirds of donors would experience one or more side effects, but these would usually be mild and well tolerated.},
	keywords = {*Blood Donors, Adolescent, Adult, Blood Cell Count / drug effects, Dose-Response Relationship, Drug, effects / *pharmacology, Female, Granulocyte Colony Stimulating Factor, Recombinant / adverse, Granulocytes / *cytology, Humans, Male, Middle Aged, Reference Values},
	issn = {0041-1132 (Print) 0041-1132 (Linking)},
	author = {McCullough,J. and Clay,M. and Herr,G. and Smith,J. and Stroncek,D.}
}
