@article {1056,
	title = {Peripheral blood stem cell mobilization and apheresis: analysis of adverse events in 94 normal donors},
	journal = {Bone Marrow Transplant},
	volume = {24},
	year = {1999},
	note = {Murata, M Harada, M Kato, S Takahashi, S Ogawa, H Okamoto, S Tsuchiya, S Sakamaki, H Akiyama, Y Kodera, Y Multicenter Study Research Support, Non-U.S. Gov{\textquoteright}t England Bone marrow transplantation Bone Marrow Transplant. 1999 Nov;24(10):1065-71.},
	month = {Nov},
	pages = {1065 - 71},
	edition = {36495},
	abstract = {Adverse events were analyzed in 94 normal donors who underwent PBSC harvest with G-CSF. The median dose of G-CSF was 9.7 microg/kg/day (range, 2.0-16.7), and the duration of administration was 4-6 days. Frequent symptoms were bone pain (71\%), general fatigue (33\%), headache (28\%), insomnia (14\%), anorexia (11\%), nausea and/or vomiting (11\%). One donor (1\%) developed grade 3 toxicity bone pain (WHO criteria). WBC counts and ANC increased during G-CSF administration. After leukapheresis, three donors (3\%) developed grade 3 toxicity neutropenia. Platelet counts decreased after leukapheresis. Three donors (3\%) developed grade 3 thrombocytopenia. The means of both ALP and LDH increased approximately 1.9-fold compared with pretreatment levels. In one pediatric donor (1\%), ALP was elevated to the grade 3 toxicity level. From multivariate analysis, the incidence of bone pain increased when G-CSF was given at a dose of 8.8 microg/kg/day or more, headaches were frequent in donors younger than 35 years, and the incidence of nausea and/or vomiting was high in female donors. The peak levels of WBC counts and ANC and post-treatment level of LDH increased in correspondence with the escalation of G-CSF dose. All adverse events normalized on follow-up evaluation. In conclusion, although PBSC harvest for normal donors is acceptable, care must be taken for all donors in terms of their sex and age as well as the G-CSF dose. We recommend less than 8.8 microg/kg/day as the G-CSF dose for PBSC mobilization in normal donors.},
	keywords = {*Blood Donors, Adolescent, Adult, Blood Component Removal / *adverse effects, Child, Fatigue, Female, Granulocyte Colony-Stimulating Factor / *adverse effects, Headache, Hematopoietic Stem Cell Mobilization / *adverse effects, Humans, Leukocyte Count, Male, Middle Aged, Multivariate Analysis, Nausea, Neutropenia, Pain, Platelet Count, Sleep Initiation and Maintenance Disorders, Vomiting},
	issn = {0268-3369 (Print) 0268-3369 (Linking)},
	doi = {10.1038/sj.bmt.1702038},
	author = {Murata,M. and Harada,M. and Kato,S. and Takahashi,S. and Ogawa,H. and Okamoto,S. and Tsuchiya,S. and Sakamaki,H. and Akiyama,Y. and Kodera,Y.}
}
