@article {1092,
	title = {Sustained decrease of peripheral lymphocytes after allogeneic blood stem cell aphereses},
	journal = {British Journal of Haematology},
	volume = {100},
	year = {1998},
	note = {HPC},
	pages = {695 - 7},
	abstract = {<p>48 healthy donors underwent peripheral blood stem cell (PBSC) apheresis for allogeneic transplantation beginning on day 4 of G-CSF (2 x 5 microg/kg) mobilization. In one to four (median two) large-volume mononuclear cell aphereses, a median of 55.9 x 10(9) of lymphocytes (range 21.0-109.2 x 10[9]) were collected, an amount comparable to lymphocyte numbers removed by therapeutic lymphaphereses in autoimmune diseases. Mean peripheral lymphocyte counts decreased from premobilization values of 2.31 x 10(9)/l to 1.31 x 10(9)/l at a median of 34 d (1 month) and 1.53 x 10(9)/l at a median of 327 d (11 months). The decrease in peripheral lymphocyte counts was significantly correlated with the number of lymphocytes removed and the number of aphereses. Neutrophil and platelet counts returned to normal values after 1 month whereas monocyte counts and haemoglobin concentrations were significantly decreased at 1 month but not at 11 months.</p>
},
	keywords = {*Hematopoietic Stem Cell Transplantation / ae [Adverse Effects], *Leukapheresis / ae [Adverse Effects], *Lymphopenia / et [Etiology], Female, Humans, Leukocyte Count, Male, Neutrophils, Platelet Count, Retrospective Studies},
	author = {Novotny,J. and Kadar,J. and Hertenstein,B. and Schroder,D. and Petersen,D. and Arseniev,L. and Stangel,W. and Ganser,A.}
}
