@article {1376,
	title = {Selection criteria for liver transplant donors},
	journal = {J Clin Lab Anal},
	volume = {5},
	year = {1991},
	note = {0887-8013 (Print) Journal Article},
	pages = {275 - 7},
	abstract = {As the number of successful liver transplants has increased, the demand for donors has outpaced the supply. Approximately 25\% of patients die awaiting an appropriate donor. Current criteria for assessing potential donors need to be closely examined. Fifty-six potential donors were evaluated by our transplant team by utilizing standard liver function tests (LFT{\textquoteright}s)-SGOT, SGPT, bilirubin. Additionally, a lidocaine metabolism test was performed by giving a 1 mg/kg IV dose of lidocaine over 1 minute and measuring the accumulation of the major metabolite monoethylglycinxylidide (MEGX) at 15 minutes by fluorescent polarization immunoassay (Abbott Diagnostics, Abbott Park, IL). Previous work has suggested that a MEGX less than 50 ng/mL is associated with initial non-function. Thirty-four donors were transplanted (group I) and all had initial function (all MEGX values were greater than 50). Twenty-two donors (39\%) were judged unacceptable (group II) by our transplant team and by outside centers based upon one of the following criteria: II A) elevated LFT{\textquoteright}s--8, 11 B) donor age--5, II C) donor instability--4, II D) no available recipient--3, II E) miscellaneous--2. Standard LFT{\textquoteright}s were not statistically different in the donors used and in those not used when excluding category II A. Six of seven donors excluded in group I had acceptable MEGX values indicating they may have been transplantable. Ten of 12 patients excluded in groups II B-D had normal LFT{\textquoteright}s and nine of 12 had acceptable MEGX values indicating they may have been transplantable also. In this era of organ shortage, a reevaluation of donor selection criteria utilizing new tests like MEGX may be necessary to meet the increased need.},
	keywords = {*Tissue Donors, Adolescent, Adult, Child, Child, Preschool, Female, Fluorescence Polarization Immunoassay, Humans, Infant, Lidocaine / analogs \& derivatives / blood / diagnostic use / metabolism, Liver Function Tests, Liver Transplantation / *standards, Male, Middle Aged},
	author = {Schroeder,T. J. and Pesce,A. J. and Ryckman,F. C. and Tressler,T. P. and Brunson,M. E. and Pedersen,S. H. and Tchervenkov,J. I. and Penn,I. and Alexander,J. W. and Balistreri,W. F.}
}
