@article {1464,
	title = {Fatal transfer of malignant melanoma from multiorgan donor to four allograft recipients},
	journal = {Transplantation},
	volume = {70},
	year = {2000},
	note = {0041-1337 (Print) Case Reports Journal Article},
	month = {Jul 15},
	pages = {232 - 6},
	abstract = {BACKGROUND: In this report we describe the transfer of malignant melanoma from a single donor to four solid organ transplant recipients, all of whom died from metastatic melanoma. METHODS AND CASE HISTORIES: The donor of a heart, liver, and two kidneys to four separate recipients died of intracerebral hemorrhage. The donor had no history or clinical evidence of melanoma. All four recipients, treated with standard immunosuppression protocols, developed metastatic malignant melanoma within 1 year after transplantation Three patients died within 14 months after transplantation, although the fourth, whose immunosuppressive therapy was discontinued, died of metastatic melanoma 30 months after renal transplantation. FINDINGS: Tumors from all recipients were histologically identical. Donor origin of tumor cells was confirmed by polymerase chain reaction (PCR)-based DNA analysis for polymorphic short tandem tetrameric repeats (Geneprint STR, Promega Corp., Madison, WI). DNAs from nontumorous donor tissue and tumor tissue available from three recipients tested positive for CSF1P0 alleles 10 and 12 and for TH01 alleles 6 and 7, although DNAs from nonneoplastic recipient tissues all exhibited different allelotypes. INTERPRETATION: Transmission of fatal or potentially fatal malignant tumors, notably malignant melanoma, from donor to recipient is an uncommon complication of solid organ transplantation. PCR-based genetic analysis permits definitive assignment of the source of posttransplant tumors.},
	keywords = {*Tissue Donors, Adult, Aged, DNA / analysis, Fatal Outcome, Female, Humans, Melanoma / *etiology, Middle Aged, Research Support, U.S. Gov{\textquoteright}t, P.H.S., Transplantation, Homologous},
	author = {Stephens,J. K. and Everson,G. T. and Elliott,C. L. and Kam,I. and Wachs,M. and Haney,J. and Bartlett,S. T. and Franklin,W. A.}
}
