@article {1689,
	title = {Advanced donor-origin melanoma in a renal transplant recipient: immunotherapy, cure, and retransplantation},
	journal = {Transplantation},
	volume = {66},
	year = {1998},
	note = {LR: 20111117; JID: 0132144; 0 (Antineoplastic Agents); 0 (Immunosuppressive Agents); 0 (Interferon-alpha); 0 (Recombinant Proteins); 76543-88-9 (interferon alfa-2a); ppublish},
	month = {Sep 15},
	pages = {655 - 661},
	address = {UNITED STATES},
	abstract = {BACKGROUND: A kidney transplant recipient inadvertently contracted donor-origin melanoma, which was found to be very advanced at presentation. Withdrawal of immunosuppression failed to induce rejection, and interferon-alpha was required. When florid allograft rejection was in progress, the allograft was removed, before it was recognized that the transplanted melanoma was not being simultaneously rejected. METHODS: Subsequent immunotherapy was required, which largely recapitulated treatment of recognized value in autologous melanoma and included interferon-alpha, use of cultured melanoma cells as tumor vaccine, pooled allogeneic cell vaccination, and adoptive immunotherapy using lymphokine-activated killer cells. RESULTS: Prolonged immunotherapy eradicated the widespread malignancy, and the patient went on to a successful second renal transplant, with follow-up of over 24 months. CONCLUSIONS: This unique case demonstrates the successful cure of advanced transplanted melanoma through the use of immunotherapy, which did not require sophisticated tumor vaccine technology, and successful retransplantation.},
	keywords = {Adult, Antineoplastic Agents / therapeutic use, Female, Humans, Immunosuppressive Agents / therapeutic use, Interferon-alpha / therapeutic use, Kidney Transplantation / adverse effects / immunology, Male, Melanoma / immunology / pathology, Middle Aged, Recombinant Proteins, Tissue Donors, Transplantation Immunology},
	issn = {0041-1337; 0041-1337},
	author = {Suranyi,M. G. and Hogan,P. G. and Falk,M. C. and Axelsen,R. A. and Rigby,R. and Hawley,C. and Petrie,J.}
}
