@booklet {1875,
	title = {Transmission of Angiosarcomas From a Common Multiorgan Donor to Four Transplant Recipients},
	volume = {13},
	year = {2013},
	note = {[Article]; NLM Journal Code: 100968638},
	month = {January},
	pages = {6},
	abstract = {: We describe the donor tumor transmission of metastatic angiosarcomas to four transplant recipients through transplantation of deceased-donor organs, i.e. kidneys, lung and liver, from an apparently unaffected common female multiorgan donor. Fluorescent in situ hybridization of angiosarcoma cells confirmed that the tumor was of female donor{\textquoteright}s origin in male kidney recipients. Recent literature associated increased urokinase-plasminogen-activator-receptor (uPAR) and plasma soluble urokinase-plasminogen-activator-receptor (suPAR) levels with metastatic malignancies. Now we found that, compared to baseline levels, both deceased-donor kidney recipients showed increased uPAR transcripts in mononuclear cells as well as increased plasma suPAR levels after the diagnosis of metastatic angiosarcomas, i.e. 4 months after donor tumor transmission. These results show an association of uPAR/suPAR in donor tumor transmission of metastatic angiosarcomas in humans. Copyright (C) 2013 Blackwell Publishing Ltd.; References: 1. Kauffman HM, McBride MA, Cherikh WS, Spain PC, Marks WH, Roza AM. Transplant tumor registry: Donor related malignancies. Transplantation, 2002; 74: 358-362. 2. Ahmed I, Hamacher KL. Angiosarcoma in a chronically immunosuppressed renal transplant recipient: Report of a case and review of the literature. Am J Dermatopathol, 2002; 24: 330-335. 3. Blasi F, Carmeliet P. uPAR: A versatile signaling orchestrator. Nat Rev Mol Cell Biol, 2002; 12: 932-943. 4. Riisbro R, Christensen IJ, Nielsen HJ, Brunner N, Nilbert M, Fernebro E. Preoperative plasma soluble urokinase plasminogen activator receptor as a prognostic marker in rectal cancer patients. An EORTC-Receptor and Biomarker Group collaboration. Int J Biol Markers, 2005; 20: 93-102. 5. Thomassen A, Lerberg Nielsen A, Gerke O, Johansen A, Petersen H. Duration of 18F-FDG avidity in lymph nodes after pandemic H1N1v and seasonal influenza vaccination. Eur J Nucl Med Mol Imaging, 2011; 38: 894-898. 6. Liu Y, Echtermeyer F, Thilo F, et al. The proteoglycan syndecan 4 regulates transient receptor potential canonical 6 channels via RhoA/Rho-associated protein kinase signaling. Arterioscler Thromb Vasc Biol, 2012; 32: 378-385. 7. Wuensch T, Thilo F, Krueger K, Scholze A, Ristow M, Tepel M. High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytes. Diabetes, 2010; 59: 844-849. 8. Ison MG, Hager J, Blumberg E, et al. Donor-derived disease transmission events in the United States: Data reviewed by the OPTN/UNOS Disease Transmission Advisory Committee. Am J Transplant, 2009; 9: 1929-1935. 9. Nalesnik MA, Woodle ES, Dimaio JM, et al. Donor-transmitted malignancies in organ transplantation: Assessment of clinical risk. Am J Transplant, 2011; 11: 1140-1147. 10. Zanetta L, Corada M, Grazia Lampugnani M, et al. Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications. Thromb Haemost, 2005; 93: 1041-1046. 11. Khan MM, Bradford HN, Isordia-Salas I, et al. High-molecular-weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1, and gC1qR in monocytes. Arterioscler Thromb Vasc Biol, 2006; 26: 2260-2266. 12. Kim MH, Yoo HS, Kim MY, et al. Helicobacter pylori stimulates urokinase plasminogen activator receptor expression and cell invasiveness through reactive oxygen species and NF-kappaB signaling in human gastric carcinoma cells. Int J Mol Med, 2007; 19: 689-697. 13. Lee KH, Kim SW, Kim JR. Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells. J Exp Clin Cancer Res, 2009; 28: 73. 14. Eltzschig HK, Carmeliet P. Hypoxia and inflammation. N Engl J Med, 2011; 364: 656-665.},
	keywords = {Angiosarcoma, Clinical Medicine., donor tumor transmission, Transplantation, urokinase-plasminogen-activator-receptor.},
	issn = {1600-6135},
	doi = {10.1111/j.1600-6143.2012.04301.x},
	author = {Thoning,J. and Liu,Y. and Bistrup,C. and Thomassen,A. and Borst,C. and Marcussen,N. and Tepel,M.}
}
