@booklet {1876,
	title = {Raccoon rabies virus variant transmission through solid organ transplantation.},
	volume = {310},
	year = {2013},
	note = {Status: MEDLINE; Comments: Comment in: JAMA. 2013 Jul 24;310(4):378-9; PMID: 23917287; Publishing Model: Journal available in: Print Citation processed from: Internet; NLM Journal Code: 7501160},
	month = {Jul 24},
	pages = {398},
	address = {United States},
	abstract = {<p>IMPORTANCE: The rabies virus causes a fatal encephalitis and can be transmitted through tissue or organ transplantation. In February 2013, a kidney recipient with no reported exposures to potentially rabid animals died from rabies 18 months after transplantation. OBJECTIVES: To investigate whether organ transplantation was the source of rabies virus exposure in the kidney recipient, and to evaluate for and prevent rabies in other transplant recipients from the same donor. DESIGN: Organ donor and all transplant recipient medical records were reviewed. Laboratory tests to detect rabies virus-specific binding antibodies, rabies virus neutralizing antibodies, and rabies virus antigens were conducted on available specimens, including serum, cerebrospinal fluid, and tissues from the donor and the recipients. Viral ribonucleic acid was extracted from tissues and amplified for nucleoprotein gene sequencing for phylogenetic comparisons. MAIN OUTCOMES AND MEASURES: Determination of whether the donor died from undiagnosed rabies and whether other organ recipients developed rabies. RESULTS: In retrospect, the donor\&$\#$39;s clinical presentation (which began with vomiting and upper extremity paresthesias and progressed to fever, seizures, dysphagia, autonomic dysfunction, and brain death) was consistent with rabies. Rabies virus antigen was detected in archived autopsy brain tissue collected from the donor. The rabies viruses infecting the donor and the deceased kidney recipient were consistent with the raccoon rabies virus variant and were more than 99.9\% identical across the entire N gene (1349/1350 nucleotides), thus confirming organ transplantation as the route of transmission. The 3 other organ recipients remained asymptomatic, with rabies virus neutralizing antibodies detected in their serum after completion of postexposure prophylaxis (range, 0.3-40.8 IU/mL). CONCLUSIONS AND RELEVANCE: Unlike the 2 previous clusters of rabies virus transmission through solid organ transplantation, there was a long incubation period in the recipient who developed rabies, and survival of 3 other recipients without pretransplant rabies vaccination. Rabies should be considered in patients with acute progressive encephalitis of unexplained etiology, especially for potential organ donors. A standard evaluation of potential donors who meet screening criteria for infectious encephalitis should be considered, and risks and benefits for recipients of organs from these donors should be evaluated.</p>
},
	keywords = {AIM, IM, Animals, Humans, Infectious Disease Incubation Period, Kidney Transplantation / ae [Adverse Effects], Male, Polymerase Chain Reaction, Rabies / di [Diagnosis], Rabies / pc [Prevention \& Control], Rabies / pp [Physiopathology], Rabies / tm [Transmission], Rabies Vaccines / tu [Therapeutic Use], Rabies virus / ge [Genetics], Rabies virus / ip [Isolation \& Purification], Raccoons / vi [Virology], Retrospective Studies, Tissue Donors},
	issn = {0098-7484},
	doi = {http://dx.doi.org/10.1001/jama.2013.7986},
	author = {Vora,N. M. and Basavaraju,S. V. and Feldman,K. A. and Paddock,C. D. and Orciari,L. and Gitterman,S. and Griese,S. and Wallace,R. M. and Said,M. and Blau,D. M. and Selvaggi,G. and Velasco-Villa,A. and Ritter,J. and Yager,P. and Kresch,A. and Niezgoda,M. and Blanton,J. and Stosor,V. and Falta,E. M. and Lyon,G. M.,3rd and Zembower,T. and Kuzmina,N. and Rohatgi,P. K. and Recuenco,S. and Zaki,S. and Damon,I. and Franka,R. and Kuehnert,M. J. and Transplant-Associated Rabies Virus Transmission Investigation,Team and Lyon,G. M.},
	editor = {Benator,D. and Bennett,S. and Blythe,D. and Bohen,E. and Buchanan,B. D. and Burgess,T. H. and Condori-Condori,R. E. and Drew,C. P. and Gabel,J. and Gordin,F. M. and Hightower,D. and Hodge,J. J. and Jackson,F. and Kan,V. and Krulak,D. C. and Muehlenbachs,A. and Smith,T. G. and Shieh,W. J. and Vancil,G. W. and Wade,B. H. and Williams,C. and Wu,X.}
}
