@article {4039,
	title = {Donor and Recipient BKV-Specific IgG Antibody and Posttransplantation BKV Infection:  A Prospective Single-Center Study.},
	journal = {//Transplantation},
	volume = {95},
	year = {2013},
	month = {2013},
	pages = {896 - 902},
	publisher = {(1) Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA.(2) Department of Medicine, Medical College of Wisconsin, Milwaukee, WI.(3) Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI.(4) Pediatric Nephr},
	address = {(C) 2013 Lippincott Williams \& Wilkins, Inc.},
	abstract = {Background: The study evaluated the relationship of pretransplantation BK virus (BKV)-specific donor and recipient serostatus to posttransplantation BKV infection., Methods: Two hundred forty adult de novo kidney-only recipients and 15 pediatric recipients were prospectively enrolled and followed for a minimum of 18 months. Pretransplantation BKV serostatus was available for 192 adult and 11 pediatric donor-recipient pairs. Based on BKV-specific IgG enzyme immunoassay >=8 units, subjects were divided into four groups: D+R+, D+R-, D-R+, and D-R-. BKV DNA surveillance was performed at 1, 3, 6, 12, and 24 months. The outcomes studied were development of any BKV infection, viremia, and significant viremia (>=10,000 copies/mL plasma)., Results: Of the 192 adult subjects (D+R- [n=41], D+R+ [n=42], D-R+ [n=41], and D-R- [n=68]), 89 of 192 developed any BKV infection and 62 of 89 developed BK insignificant viremia (n=33) and significant viremia (n=29). Any BKV infection developed in 25 of 41, 22 of 42, 17 of 41, and 25 of 68 in the D+R-, D+R+, D-R+, and D-R- groups, respectively. Any viremia (20 of 41) and significant viremia (10 of 41) seen in the D+R- group was significantly higher than other groups (P=0.014). In 11 pediatric recipients, infection was seen only in the D+R- group. Overall, infection was highest in the D+R- group and lowest in the D-R- group., Conclusions: BKV serostatus can be used to risk stratify patients for posttransplantation infection., (C) 2013 Lippincott Williams \& Wilkins, Inc.},
	keywords = {BKV infection, BKV-specific antibody, kidney transplant},
	isbn = {0041-1337},
	author = {Sood, Puneet and Senanayake, Shamila and Sujeet, Kumar and Medipalli, Radhika and Van-Why, Scott and Cronin, David and Johnson, Christopher and Hariharan, Sundaram}
}
