@article {4097,
	title = {Fulminant hepatitis following primary herpes simplex virus infection.},
	journal = {Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia//Saudi J Kidney Dis Transpl},
	volume = {22},
	year = {2011},
	month = {2011},
	pages = {107 - 11},
	publisher = {Al Midani,A. Renal Transplant Unit, Royal Free Hospital, London, UK. ammar_midani@yahoo.co.uk},
	address = {Saudi Arabia},
	abstract = {Fulminant hepatic failure (FHF) is a rare but well-recognized complication of primary herpes simplex virus (HSV) infection in immunocompromised patients. Here, we report two cases of acute hepatitis and FHF secondary to primary HSV type 1 infection following renal transplantation in the absence of any mucocutaneous manifestation. High levels of HSV type-1 DNA were detected in the blood. Both patients were seronegative for HSV 1 and HSV 2 immunoglobulin G (IgG) before transplantation, whereas the donor of patient 1 was HSV 1 IgG-positive but had no viremia and the donor of patient 2 was HSV-seronegative. Patient 1 recovered with acyclovir and immunoglobulin whereas patient 2 did not respond and succumbed to death. HSV-seronegative patients are potentially at risk of developing severe primary HSV disease following transplantation, particularly in the absence of routine anti-viral prophylaxis. HSV infection should always be excluded in transplant patients with hepatic dysfunction.},
	keywords = {*Hepatitis, Viral, Human/vi [Virology], *Herpes Simplex/vi [Virology], *Herpesvirus 1, Human/py [Pathogenicity], *Kidney Transplantation/ae [Adverse Effects], *Liver Failure, Acute/vi [Virology], Acyclovir/tu [Therapeutic Use], Adult, Antiviral Agents/tu [Therapeutic Use], Biopsy, Fatal Outcome, Female, Hepatitis, Viral, Human/di [Diagnosis], Hepatitis, Viral, Human/dt [Drug Therapy], Herpes Simplex/di [Diagnosis], Herpes Simplex/dt [Drug Therapy], Herpesvirus 1, Human/ge [Genetics], Humans, Immunoglobulins, Intravenous/tu [Therapeutic Use], Immunosuppressive Agents/tu [Therapeutic Use], Liver Failure, Acute/di [Diagnosis], Liver Failure, Acute/dt [Drug Therapy], Male, Middle Aged, RNA, Viral/bl [Blood], Tomography, X-Ray Computed, Treatment Outcome},
	isbn = {1319-2442},
	author = {Al Midani, A and Pinney, J and Field, N and Atkinson, C and Haque, T and Harber, M}
}
