@article {4100,
	title = {Acute lung Injury in a healthy donor during mobilization of peripheral blood stem cells using granulocyte-colony stimulating factor alone.},
	journal = {Haematologica//Haematologica},
	volume = {90},
	year = {2005},
	month = {2005},
	pages = {ECR10},
	publisher = {Arimura,Kosei. Department of Hematology and Immunology, Kagoshima University Hospital, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan.},
	address = {Italy},
	abstract = {Granulocyte-colony stimulating factor (G-CSF), a hematopoietic growth factor, is widely used to accelerate recovery from neutropenia after severe chemotherapy, both decreasing the risk of infection and mobilizing peripheral blood stem cells. Adverse effects occur with G-CSF use in approximately 30\% of cases, comprised predominantly of bone pain, headache, and general fatigue. Pulmonary toxicity is very rare. Here, we describe a healthy donor for allogeneic hematopoietic stem cell transplantation who developed acute lung injury (ALI) after 4 days of G-CSF administration. Among the serum cytokines examined, only Interleukin (IL)-1beta level was elevated in this case. As a high level of IL-1beta was detected at the onset of ALI, on day 4 after G-CSF administration, and decreased to below the level of detection on day 11, it is possible in a certain part that IL-1beta was involved in the onset of G-CSF-related ALI in the present case. Granulocyte-colony stimulating factor (G-CSF) is commonly administered to healthy donors to mobilize peripheral blood stem cells (PBSC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Adverse events from G-CSF use in healthy donors have been described in approximately 30\% of cases, and are comprised predominantly of bone pain, headache, and general fatigue. Pulmonary complications caused by G-CSF include cough, dyspnea, and interstitial or alveolar pulmonary edema with mild-to-severe deterioration of blood oxygen level. Few cases of acute respiratory distress syndrome (ARDS) following G-CSF administration have been reported. The present report describes a healthy donor for allo-HSCT with acute lung injury (ALI) after 4 days of G-CSF administration. The cytokine-related mechanisms of G-CSF administration that contribute to ALI are discussed.},
	keywords = {*Granulocyte Colony-Stimulating Factor/ae [Adverse Effects], *Hematopoietic Stem Cell Mobilization/ae [Adverse Effects], *Respiratory Distress Syndrome, Adult/ci [Chemically Induced], *Tissue Donors, Hematopoietic Stem Cell Mobilization/mt [Methods], Hematopoietic Stem Cell Transplantation, Humans, Transplantation, Homologous},
	isbn = {1592-8721},
	author = {Arimura, Kosei and Inoue, Hirosaka and Kukita, Toshimasa and Matsushita, Kakushi and Akimot, Masaki and Kawamata, Nakaaki and Yamaguchi, Akihiko and Kawada, Hideaki and Ozak, Atsuo and Arima, Naomichi and Te, Chuwa}
}
