@article {4104, title = {Graft-vs-host disease as a complication of lung transplantation.}, journal = {The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation//J Heart Lung Transplant}, volume = {25}, year = {2006}, month = {2006}, pages = {1175 - 7}, publisher = {Smith,Douglas M. Department of Pathology, Baylor University Medical Center, Dallas, Texas 75246, USA. dsmith@baylorhealth.edu}, address = {United States}, abstract = {We report a rare case of acute graft-vs-host disease (aGVHD) after a lung transplant. The patient presented with advanced disease manifested by skin rash, fever, diarrhea, liver dysfunction and severe pancytopenia. He went on to die of sepsis and multi-organ failure. aGVHD is a disease often confused with drug reactions or viral infection; therefore, it is important to have a high index of suspicion and to confirm the diagnosis early with tests for donor cell chimerism. Effective treatment is elusive but we are learning a great deal about the underlying mechanisms of this disease and hope to develop better treatment.}, keywords = {*Graft vs Host Disease/et [Etiology], *Lung Transplantation/ae [Adverse Effects], *Postoperative Complications/im [Immunology], Chimerism, Diagnosis, Differential, Disease Progression, Fatal Outcome, Graft vs Host Disease/di [Diagnosis], Graft vs Host Disease/im [Immunology], Histocompatibility Testing, Humans, Lung Transplantation/im [Immunology], Lung Transplantation/pa [Pathology], Male, Middle Aged, Postoperative Complications/di [Diagnosis], T-Lymphocytes/pa [Pathology], Tissue Donors}, isbn = {1557-3117}, author = {Smith, Douglas M and Agura, Edward D and Ausloos, Ken and Ring, W Steves and Domiati-Saad, Rana and Klintmalm, Goran B} }