@article {4137, title = {Fatal delayed hemolytic transfusion reaction associated with anti-Di(b) and anti-E.}, journal = {Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis//Transfus Apheresis Sci}, volume = {47}, year = {2012}, month = {2012}, pages = {263 - 8}, publisher = {Hatano,Yuichiro. Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan. yuha@gifu-u.ac.jp}, address = {England}, abstract = {We report the death of a 61-year-old Japanese man massively transfused during and after emergency aortic surgery. Postoperative on day 8, he died after cardiac arrest associated with hyperkalemia. Indirect antiglobulin testing demonstrated both anti-Di(b) and anti-E antibodies pre-transfusion, and elevation of their titers as the delayed hemolytic transfusion reaction evolved. Monocyte monolayer assay (induction of reactive monocytes) and flow cytometry (increase of IgG1 and/or IgG3) gave evidence of the clinical significance of both antibodies. Anti-Di(b) must be considered when an antibody to a high incidence antigen is found in Japanese and other Mongoloid populations.Copyright {\textcopyright} 2012 Elsevier Ltd. All rights reserved.}, keywords = {*Blood Group Incompatibility/bl [Blood], *Erythrocyte Transfusion/mt [Methods], *Rh-Hr Blood-Group System/im [Immunology], Aneurysm, Dissecting/su [Surgery], Antibodies/im [Immunology], Blood Group Incompatibility/im [Immunology], Cardiac Surgical Procedures/mt [Methods], Erythrocyte Transfusion/ae [Adverse Effects], Humans, Isoantibodies/im [Immunology], Male, Middle Aged, Phenotype}, isbn = {1473-0502}, author = {Hatano, Yuichiro and Otsuka, Setsuko and Chousa, Mitsuhiro and Saito, Shunnichi and Nollet, Kenneth E and Ohto, Hitoshi and Shimabukuro, Katsuya and Takemura, Hirofumi and Hara, Akira} }