@article {4167,
	title = {The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study.},
	journal = {Blood//Blood},
	volume = {117},
	year = {2011},
	note = {Comment in: Blood. 2011 Apr 21;117(16):4163-4; PMID: 21511960},
	month = {2011},
	pages = {4218 - 25},
	publisher = {Vlaar,Alexander P J. Department of Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands. a.p.vlaar@amc.uva.nl},
	address = {United States},
	abstract = {Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related morbidity and mortality. Both antibodies and bioactive lipids that have accumulated during storage of blood have been implicated in TRALI pathogenesis. In a single-center, nested, case-control study, patients were prospectively observed for onset of TRALI according to the consensus definition. Of 668 patients, 16 patients (2.4\%) developed TRALI. Patient-related risk factors for onset of TRALI were age and time on the cardiopulmonary bypass. Transfusion-related risk factors were total amount of blood products (odds ratio [OR] = 1.2; 95\% confidence interval [CI], 1.03-1.44), number of red blood cells stored more than 14 days (OR = 1.6; 95\% CI, 1.04-2.37), total amount of plasma (OR = 1.2; 95\% CI, 1.03-1.44), presence of antibodies in donor plasma (OR = 8.8; 95\% CI, 1.8-44), and total amount of transfused bioactive lipids (OR = 1.0; 95\% CI, 1.00-1.07). When adjusted for patient risk factors, only the presence of antibodies in the associated blood products remained a risk factor for TRALI (OR = 14.2; 95\% CI, 1.5-132). In-hospital mortality of TRALI was 13\% compared with 0\% and 3\% in transfused and nontransfused patients, respectively (P < .05). In conclusion, the incidence of TRALI is high in cardiac surgery patients and associated with adverse outcome. Our results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies.},
	keywords = {*Acute Lung Injury/ep [Epidemiology], *Blood Transfusion/ae [Adverse Effects], *Cardiac Surgical Procedures/ae [Adverse Effects], Acute Lung Injury/th [Therapy], Aged, Aged, 80 and over, Case-Control Studies, Female, Humans, Incidence, Male, Middle Aged, Prospective Studies, Risk Factors, Treatment Outcome},
	isbn = {1528-0020},
	author = {Vlaar, Alexander P J and Hofstra, Jorrit J and Determann, Rogier M and Veelo, Denise P and Paulus, Frederique and Kulik, Wim and Korevaar, Johanna and de Mol, Bas A and Koopman, Marianne M W and Porcelijn, Leendert and Binnekade, Jan M and Vroom, Margreeth B and Schultz, Marcus J and Juffermans, Nicole P}
}
