@article {4249,
	title = {The differentiation of delayed hemolytic and delayed serologic transfusion reactions: incidence and predictors of hemolysis.},
	journal = {Transfusion//Transfusion},
	volume = {35},
	year = {1995},
	month = {1995},
	pages = {26 - 32},
	publisher = {Vamvakas,E C. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.},
	address = {UNITED STATES},
	abstract = {BACKGROUND: After differentiation of the entities of clinically detectable delayed hemolytic (DHTR) and delayed serologic transfusion reactions (DSTR), previous investigators calculated a DHTR:DSTR incidence ratio of 18:72 from a retrospective review of patients with serologic evidence of DHTR or DSTR. There are no published data on factors that may influence the occurrence of DHTR versus DSTR in a given patient., STUDY DESIGN AND METHODS: Retrospective review was conducted of 292 patients at the Mayo Clinic who, between 1980 and 1992, received a clinical diagnosis of DHTR or DSTR concurrently with a serologic diagnosis. Red cell alloantibody specificity, the activity of the patient{\textquoteright}s reticuloendothelial system, and concurrent immunosuppression were evaluated as potential predictors of the occurrence of DHTR versus DSTR in different patients., RESULTS: The incidence of DHTR or DSTR was 1 in 1899 allogeneic red cell units transfused, with a DHTR:DSTR ratio of 36:64. Alloantibody specificity was the only variable that affected the occurrence of DHTR versus DSTR at the clinical level, with the anti-Jka and anti-Fya specificities, as well as multiple coexisting specificities, significantly associated with detectable hemolysis (p < 0.05)., CONCLUSION: Clinically detectable DHTRs are found to occur more commonly than previously believed when the clinical and serologic diagnoses are made concurrently and appropriate work-ups for hemolysis are ordered. The association of certain alloantibody specificities with detectable DHTRs may have implications for clinical transfusion practice.},
	keywords = {*Blood Group Incompatibility/et [Etiology], *Blood Transfusion/ae [Adverse Effects], *Hemolysis, Adult, Aged, Blood Group Antigens/im [Immunology], Blood Group Incompatibility/ep [Epidemiology], Female, Humans, Incidence, Isoantibodies/bl [Blood], Male, Middle Aged},
	isbn = {0041-1132},
	author = {Vamvakas, E C and Pineda, A A and Reisner, R and Santrach, P J and Moore, S B}
}
