@article {4429,
	title = {Platelet transfusions from D+ donors to D- patients: a 10-year follow-up study of 1014 patients.},
	journal = {Transfusion},
	volume = {51},
	year = {2011},
	note = {Comment in: Transfusion. 2011 Jun;51(6):1132-5; PMID: 21658033},
	month = {2011},
	pages = {1163 - 9},
	publisher = {Cid,Joan. Hemotherapy and Hemostasis Department, Hospital Clinic, IDIBAPS, Barcelona, Spain. jcid@clinic.ub.es},
	address = {United States},
	abstract = {BACKGROUND: Current guidelines recommend that platelets (PLTs) from D- donors should be given to D- patients. However, such evidence comes from studies with a limited number of included patients that reported an incidence of anti-D alloimmunization to be up to 19\%. We thus decided to extend these findings by examining anti-D alloimmunization at our institution, where PLT transfusions from D+ donors are transfused to D- patients because of logistic constraints., STUDY DESIGN AND METHODS: From April 1999 to December 2009, we retrospectively reviewed the clinical and transfusion records of all D- patients who received PLT transfusions from D+ donors at our hospital. PLT concentrates (PCs) were obtained from apheresis and from whole blood donations. RhIG was not administered after the transfusion of PCs from D+ donors. The antibody screen test to detect anti-D was performed by low-ionic-strength solution indirect antiglobulin test using the gel test., RESULTS: Our series comprises 1014 D- patients who received 5128 PLT transfusions from D+ donors (89\% were pooled PCs). We had 315 (31.1\%) patients who had a blood sample to analyze the presence of anti-D 4 or more weeks after the first D+ PLT transfusion with a median follow-up of 29 weeks (range, 4-718 weeks). Anti-D developed in 12 (3.8\%) of these 315 patients., CONCLUSIONS: The frequency of anti-D alloimmunization of D- patients after receiving pooled PCs from D+ donors is low. The transfusion of D-incompatible pooled PCs without immunoprophylaxis to D- men or D- women without childbearing potential seems a reasonable and safe alternative.Copyright {\textcopyright} 2010 American Association of Blood Banks.},
	keywords = {*Isoantibodies/me [Metabolism], *Platelet Transfusion/ae [Adverse Effects], Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Retrospective Studies, Young Adult},
	isbn = {1537-2995},
	author = {Cid, Joan and Carbasse, Gloria and Pereira, Arturo and Sanz, Cristina and Mazzara, Roberto and Escolar, Gines and Lozano, Miguel}
}
