@article {4450,
	title = {Exposure to ABO-nonidentical blood associated with increased in-hospital mortality in patients with group A blood.},
	journal = {Transfusion},
	year = {2015},
	month = {2015},
	publisher = {(1) Transfusion Research Program,(2) Department of Medicine, McMaster University, Hamilton, Ontario, Canada,(3) Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, Canada},
	address = {(C) 2015 John Wiley \& Sons, Ltd},
	abstract = {<p>BACKGROUND: Transfusing ABO-compatible blood avoids most acute hemolytic reactions, but donor units that are ABO compatible are not necessarily ABO identical. Emerging data have raised concerns that ABO-nonidentical blood products lead to adverse outcomes., STUDY DESIGN AND METHODS: A large multihospital registry (Transfusion Registry for Utilization, Surveillance, and Tracking) was used to determine the association between exposure to ABO-nonidentical blood and in-hospital mortality. Cox regression analyses controlled for sex, age, hemoglobin, creatinine, and in-hospital interventions and stratified by age of blood and admission year., RESULTS: Data from 18,843 non-group O patients admitted between 2002 and 2011 and receiving at least 1 unit of blood were analyzed. Overall, group A patients had significantly increased risk of in-hospital death upon receiving a nonidentical unit (RR, 1.79; 95\% CI, 1.20-2.67; p = 0.005). There was no evidence of increased risk for group B or AB patients. Similar results were seen when only patients with circulatory disorders were considered. When patients with injury or poisoning were excluded, both group A and B patients had significantly increased risk of in-hospital death., CONCLUSION: Our study demonstrates an adverse effect of ABO-nonidentical blood in a broad range of patients with group A blood, after adjustment for potential confounders. Further research in this area is required to study possible mechanisms. Increased mortality associated with exposure to nonidentical blood in these patients would have a substantial impact at the population level; it would challenge how blood suppliers manage inventory and recruit donors and how health care providers administer blood., (C) 2015 John Wiley \&amp; Sons, Ltd</p>},
	isbn = {0041-1132},
	author = {Pai, Menaka and Cook, Richard and Barty, Rebecca and Eikelboom, John and Lee, Ker-Ai and Heddle, Nancy}
}
