01138nas a2200121   4500008003900000245013400039210006900173300000600242490000700248520069700255100001500952856004900967       1989                          d00aAnaphylaxis to infusion of autologous bone marrow: An apparent reaction to self, mediated by IgE antibody to bovine serum albumin0 aAnaphylaxis to infusion of autologous bone marrow An apparent re  a10 v833 aA case of anaphylaxis during autologous bone marrow infusion is reported. The patient was demonstrated to be skin test positive to fetal calf serum used in the cryopreservation of his bone marrow cells. The patient's serum was demonstrated to contain IgE antibody directed against bovine serum albumin. A second aliquot of the patient's bone marrow preparation was depleted of contaminating bovine proteins, and the patient successfully received a transplant and was engrafted. Clinicians need to be aware that the increasing use of biologic response modifiers, both as whole cells and effector molecules manipulated or produced in vitro, may lead to cryptic reactions to xenogeneic proteins.1 aMacy, Eric  uhttps://www.notifylibrary.org/reference/4618