02133nas a2200181   4500008003900000245007000039210006900109490000700178520158000185653001101765653001901776653002901795653002201824653002601846100001301872700001701885856004901902       2014                          d00aDonor transmitted and de novo cancer after liver transplantation.0 aDonor transmitted and de novo cancer after liver transplantation0 v283 aCancers in solid organ recipients may be classified as donor transmitted, donor derived, de novo or recurrent. The risk of donor-transmitted cancer is very low and can be reduced by careful screening of the donor but cannot be abolished and, in the United Kingdom series is less than 0.03%. For donors with a known history of cancer, the risks will depend on the nature of the cancer, the interventions given and the interval between diagnosis and organ donation. The risks of cancer transmission must be balanced against the risks of death awaiting a new graft and strict adherence to current guidelines may result increased patient death. Organs from selected patients, even with high-grade central nervous system (CNS) malignancy and after a shunt, can, in some circumstances, be considered. Of potential donors with non-CNS cancers, whether organs may be safely used again depends on the nature of the cancer, the treatment and interval. Data are scarce about the most appropriate treatment when donor transmitted cancer is diagnosed: sometimes substitution of agents and reduction of the immunosuppressive load may be adequate and the impact of graft removal should be considered but not always indicated. Liver allograft recipients are at increased risk of some de novo cancers, especially those grafted for alcohol-related liver disease and hepatitis C virus infection. The risk of lymphoproliferative disease and cancers of the skin, upper airway and bowel are increased but not breast. Recipients should be advised to avoid risk behavior and monitored appropriately.10aCancer10aDe novo cancer10aDonor transmitted cancer10aImmunosuppression10aLiver Transplantation1 aDesai, R1 aNeuberger, J  uhttps://www.notifylibrary.org/reference/4627