01872nas a2200157   4500008003900000245009200039210006900131260000800200300000600208490000700214520139900221100001501620700001301635700001701648856004901665       2017                          d00aStrongyloides stercoralis in solid organ transplantation: early diagnosis gets the worm0 aStrongyloides stercoralis in solid organ transplantation early d  cAug  a60 v223 aStrongyloidiasis is a parasitic infection affecting millions of people worldwide. Complications of infection are strongly associated with alcoholism, immunosuppression, and organ transplantation. Delayed diagnosis results in hyperinfection syndrome and disseminated strongyloidiasis leading to mortality rates approaching 80%. Early detection, and prevention of infection and transmission are key to diminish this illness.
RECENT FINDINGS:

In this review, we cover the basic concepts in immunity, immunosuppression, and disorder necessary for understanding the infectious syndromes associated with Strongyloides stercoralis infection. Focused discussion on donor-derived transmission and recipient risk in solid organ transplantation is presented. Current methodology for diagnosis, screening algorithms, and treatment are also reviewed.
SUMMARY:

Strongyloidiasis complicated by hyperinfection and dissemination remains associated with a poor outcome. The poor outcome pleads for a high level of suspicion and aggressive treatment in at-risk patients. As the population of transplant patients continues to increase, the risk of infection also increases, compelling us to address this highly fatal infectious complication in solid organ transplantation (SOT). Here we review the pathology, immunology, diagnosis, and treatment of strongyloides infection in the immunosuppressed SOT population.1 aMobley, CM1 aDhala, A1 aGhobrial, RM  uhttps://www.notifylibrary.org/reference/4681