01909nas a2200229   4500008003900000245005800039210005800097260000800155520126400163100001801427700001401445700001401459700001501473700003401488700002001522700002201542700002001564700001501584700001401599700001701613856004901630       2019                          d00aDengue virus transmission from live donor liver graft0 aDengue virus transmission from live donor liver graft  cJan3 aArboviral transmission through transplanted organs is rare. We report a highly probable case of dengue viral transmission during live donor liver transplantation. Fever with severe thrombocytopenia was observed in the donor and recipient within 6 and 9 days after transplantation, respectively. Dengue diagnosis was confirmed by testing blood and explant tissue from the donor and recipient using dengue-specific NAT (nucleic acid testing) and serology. Serology indicated the donor had secondary dengue infection that ran a mild course. However, the dengue illness in the recipient was severe and deteriorated rapidly, eventually proving fatal. The recipient's explant liver tissue tested negative for viral RNA indicative of a pretransplant naïve status. The prM-Envelope gene sequence analysis of the donor and recipient viral RNA identified a similar serotype (DENV1) with almost 100% sequence identity in the envelope region. Molecular phylogenetic analysis of donor and recipient viral envelope sequences with regional and local dengue strains further confirmed their molecular similarity, suggesting a probable donor-to-recipient transmission via organ transplantation. Screening of living donors for dengue virus may be considered in endemic regions.1 aMathew, Shaji1 aMenon, VP1 aMenon, VP1 aMallick, S1 aAmma, Sivasankara, Pillai Tha1 aBalakrishnan, D1 aGopalakrishnan, U1 aMenon, Narayana1 aAthira, PP1 aJagan, OA1 aSurendran, S  uhttps://www.notifylibrary.org/reference/4808