01726nas a2200193   4500008003900000245010000039210006900139260000800208300000700216490000700223520116800230100001301398700001201411700001601423700001301439700001501452700001601467856004901483       2018                          d00aMorbidity and mortality of hepatic right lobe living donors: systematic review and perspectives0 aMorbidity and mortality of hepatic right lobe living donors syst  cJun  a690 v273 aBackground and aims: The main restriction in the development of adult-adult Living Donor Liver Transplantation (LDLT) is the risk of morbidity and mortality for donors, which raises ethical questions. The objectives of this study are to review published studies dealing with morbidity and mortality in LDLT and to identify the proposed management and strategies for preventing donor mortality and morbidity in LDLT.
Methods: The Medline database was searched from 2000 to 2017 using the MeSH terms "liver transplantation" and "morbidity" or "mortality" in combination with keywords "living donor liver transplantation".
Results: Among the 382 articles obtained, 43 articles were relevant for morbidity, 15 for mortality and 6 for both morbidity and mortality. Twenty-three papers reported donor deaths. The major cause of death was sepsis (30%). Morbidity ranged from 10% to 78.3% depending on the studies.
Conclusions: The living donors' morbidity and mortality is high, currently representing the main restriction in the development of LDLT. Some promising techniques, such as the donor portal vein flow modulation could lead to the further development of LDLT.1 aBrige, P1 aHery, G1 aChopinet, S1 aPalen, A1 aAzoulay, D1 aGregoire, E  uhttps://www.notifylibrary.org/reference/4943