01829nas a2200205   4500008003900000245013600039210006900175300000600244490000700250520120900257100001401466700001301480700001401493700001401507700001401521700001301535700001201548700001401560856004901574       2023                          d00aA Rare Case of Donor-Origin Intrahepatic Cholangiocarcinoma After Liver Transplantation for Hepatocellular Carcinoma: A Case Report0 aRare Case of DonorOrigin Intrahepatic Cholangiocarcinoma After L  a40 v553 aBackground: Tumors may develop in the grafted liver after liver transplantation for hepatocellular carcinoma, most of which are hepatocellular carcinoma recurrences and are rarely of donor origin. We report a rare case of donor-origin intrahepatic cholangiocarcinoma in a liver allograft after liver transplantation for hepatocellular carcinoma.

Methods: A man in his 60s underwent liver transplantation for hepatocellular carcinoma with hepatitis C virus cirrhosis. The donor was a braindead woman in her 60s who had no history of malignancy.

Results: Three years and 5 months after liver transplantation, a tumor developed in the allograft. Computed tomography scans showed a 40-mm tumor that was atypical for hepatocellular carcinoma. Tumor biopsy was most suggestive of intrahepatic cholangiocarcinoma. Fluorescence in situ hybridization of the tumor showed an XX signal pattern, suggesting that it originated from the donor liver. Whole exome sequencing analysis strongly suggested that the tumor was an intrahepatic cholangiocarcinoma derived from the donor.

Conclusions: Although donor-origin cancer after liver transplantation is extremely rare, it should be considered for adequate treatment.1 aUemoto, Y1 aTaura, K1 aYamada, Y1 aTakeda, H1 aNakano, S1 aTakai, A1 aHaga, H1 aHatano, E  uhttps://www.notifylibrary.org/reference/5080