02569nas a2200301   4500008003900000245019700039210006900236260000800305300001300313490000800326520155700334100002401891700002101915700002501936700002901961700001401990700002302004700002202027700002002049700001902069700001902088700002302107700002002130700002402150700002202174700002302196856004802219       2006                          d00aHaematological malignancies developing in previously healthy individuals who received haematopoietic growth factors: report from the Research on Adverse Drug Events and Reports (RADAR) project0 aHaematological malignancies developing in previously healthy ind  cDec  a642 - 500 v1353 aPegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) and granulocyte colony-stimulating factor (G-CSF) promote haematopoietic progenitor cell maturation. We reviewed the findings for healthy volunteers/donors who developed haematological malignancies following PEG-rHuMGDF or G-CSF administration. Information was reviewed for three of 538 volunteers who received PEG-rHuMGDF in clinical trials and two of 200 donors who underwent G-CSF mobilised stem cell harvesting procedures for sibling stem cell transplants. Mantle cell, diffuse large B-cell lymphoma and chronic lymphocytic leukaemia were diagnosed 1-5 years after PEG-rHuMGDF exposure among three volunteers. For one patient, thrombocytopenia due to autoantibodies to PEG-rHuMGDF developed shortly after PEG-rHuMGDF administration and persisted until chemotherapy was administered. All three achieved complete remission, although one patient relapsed. Acute myeloid leukaemia was diagnosed 4 and 5 years after G-CSF mobilisation in two donors who underwent peripheral blood stem cell donation for sibling allogeneic haematopoietic stem cell transplantation. Following intensive chemotherapy, one died from acute leukaemia and the second is in complete remission. Controversy exists over the appropriateness of administering haematopoietic growth factors to healthy individuals. While a causal relationship with haematological malignancies cannot be demonstrated, long-term follow-up among healthy individuals who receive haematopoietic growth factors is needed.1 aBennett, Charles, L1 aEvens, Andrew, M1 aAndritsos, Leslie, A1 aBalasubramanian, Lakshmi1 aMai, Mark1 aFisher, Matthew, J1 aKuzel, Timothy, M1 aAngelotta, Cara1 aMcKoy, June, M1 aVose, Julie, M1 aBierman, Philip, J1 aKuter, David, J1 aTrifilio, Steven, M1 aDevine, Steven, M1 aTallman, Martin, S  uhttps://www.notifylibrary.org/reference/162