02032nas a2200241   4500008004100000022004200041245004100083210003900124250001000163260001200173300001200185490000700197520124900204653006401453653007001517653002801587653002701615653001101642653004101653653003701694100001101731856004801742       2005                        eng d  a0188-4409 (Print) 0188-4409 (Linking)00aPrions: who should worry about them?0 aPrions who should worry about them  a38637  cNov-Dec  a622 - 70 v363 aPrion diseases, also called transmissible spongiform encephalopathies (TSEs), are a family of neurodegenerative disorders affecting both humans and animals. They are caused by the accumulation of an abnormal form of a protein known as prion that results in neuronal death and a characteristic spongiform appearance of the brain tissue. Human prion diseases can be sporadic, acquired or hereditary. Acquired prion diseases have been linked to entering contaminated food into the human food chain, failure to completely disinfect or sterilize contaminated surgical instruments, patients receiving tissues and organs from infected donors, recipients of blood and other biological contaminated products, and potentially to cross infection in dental procedures. At present, there is unfortunately no efficient therapy that can be administered to clinically infected patients with prion diseases. Moreover, there are no simple diagnostic tests that can be used to show the agent of transmissible spongiform encephalopathy during the preclinical phase of the disease. Therefore, to prevent the spread of this emerging infectious agent it is necessary to implement several health control strategies and maintain surveillance for subclinical infections.10a*Communicable Diseases, Emerging / pathology / prevention &10a*Prion Diseases / pathology / prevention & control / transmission10a*Prions / pathogenicity10acontrol / transmission10aHumans10aInfection Control / methods / trends10aSterilization / methods / trends1 aEna, J  uhttps://www.notifylibrary.org/reference/485