02634nas a2200313   4500008004100000022004200041245009900083210006900182250001000251260001000261300001300271490000700284520167400291653005201965653001002017653005902027653003402086653001102120653001102131100001602142700001502158700001602173700001402189700001402203700001702217700001702234700002102251856004802272       2001                        eng d  a0028-3878 (Print) 0028-3878 (Linking)00aCreutzfeldt-Jakob disease after receipt of a previously unimplicated brand of dura mater graft0 aCreutzfeldtJakob disease after receipt of a previously unimplica  a37007  c45383  a1080 - 30 v563 aBACKGROUND: Iatrogenic Creutzfeldt-Jakob disease (CJD) transmission via dura mater grafts has been reported in many countries. In September 1998, a 39-year-old Colorado woman was reported as having suspected CJD after receiving a dura mater graft 6 years earlier. METHODS: An investigation was initiated to confirm the diagnosis of CJD and assess the possible source of CJD transmission. The authors determined the presence or absence of other known CJD risk factors, checked for epidemiologic evidence of possible CJD transmission via neurosurgical instruments, and evaluated the procedures used in the collection and processing of the graft, including whether the donor may have had CJD. RESULTS: The CJD diagnosis was confirmed in the dural graft recipient by neuropathologic and immunodiagnostic evaluation of the autopsy brain tissue. She had no history of receipt of cadaveric pituitary hormones or corneal grafts or of CJD in her family. The authors found no patients who underwent a neurosurgical procedure within 6 months before or 5 months after the patient's surgery in 1992 who had been diagnosed with CJD. The dura mater was obtained from a 57-year-old man with a history of dysarthria, ataxia, and behavioral changes of uncertain origin. The graft was commercially prepared by use of a process that included treatment with 0.1 N sodium hydroxide and avoided commingling of dura from different donors. CONCLUSIONS: The patient's age, absence of evidence for other sources of CJD, the latent period, and the report of an unexplained neurologic illness in the donor of the dura mater indicate that the graft was the most likely source of CJD in this patient.10a*Brain Tissue Transplantation / adverse effects10aAdult10aCreutzfeldt-Jakob Syndrome / diagnosis / *transmission10aDura Mater / *transplantation10aFemale10aHumans1 aHannah, E L1 aBelay, E D1 aGambetti, P1 aKrause, G1 aParchi, P1 aCapellari, S1 aHoffman, R E1 aSchonberger, L B  uhttps://www.notifylibrary.org/reference/638