02997nas a2200229   4500008004100000022001400041245009400055210006900149260000800218520233500226100001302561700001202574700001502586700001402601700001602615700001402631700002502645700001602670700001302686700002002699856004802719       2010                        ENG d  a1399-306200aMicrobiological findings of culture-positive preservation fluid in liver transplantation.0 aMicrobiological findings of culturepositive preservation fluid i  cAug3 aS. Janny, F. Bert, F. Dondero, F. Durand, P. Guerrini, P. Merckx, M.H. Nicolas-Chanoine, J. Belghiti, J. Mantz, C. Paugam-Burtz. Microbiological findings of culture-positive preservation fluid in liver transplantation. Transpl Infect Dis 2010. All rights reserved Abstract: Bacterial and fungal infections are the leading cause of mortality in liver transplant (LT) recipients. Few studies have examined the incidence of culture-positive preservation fluid (PF) and the outcome of related recipients. The aim of this study was to determine the incidence and the microbiologic findings of PF positive cultures, and to evaluate the impact on morbidity and mortality of LT recipients. A retrospective analysis of PF cultures performed after 477 LTs from cadavaric grafts between January 2001 and February 2008 was conducted. Forty-five (9.5%) PFs were found to be positive with 1 or 2 pathogens. The demographic profiles of recipients of PF with positive or negative cultures were similar. Enterobacteriaceae species were the most frequent organisms (n=30), followed by Staphylococcus aureus (n=5), coagulase-negative staphylococci (n=5), enterococci (n=4), and yeasts (n=3). Mortality rate at 1 month was not significantly different in recipients with positive or sterile PF cultures (88.1% vs. 87.7%, respectively). The rate of bacteremia among LT recipients with positive or negative PF cultures was not statistically different. Systemic infections caused by the pathogen cultured from the PF occurred in 8 (18%) of the 45 recipients, including bacteremia (4/8) or intra-abdominal sepsis (5/8). Causative organisms were Enterobacteriaceae species (n=5), Candida species (n=2), and Enterococcus faecium (n=1). Among the 8 patients who developed infection with the PF organism, 4 (50%) died in the intensive care unit (ICU) vs. an ICU mortality rate of 8% (3/37) in those who did not develop infection with the PF organism (P<0.05). Infection occurred less frequently in recipients who received antimicrobial therapy with activity against the PF isolate than in those without appropriate treatment (41% vs. 3.8%, P<0.005). Those who develop infection with organisms recovered from PF cultures appear to have high early mortality rates; therefore, appropriate antimicrobial therapy against organisms cultured from PF should be given.1 aJanny, S1 aBert, F1 aDondero, F1 aDurand, F1 aGuerrini, P1 aMerckx, P1 aNicolas-Chanoine, MH1 aBelghiti, J1 aMantz, J1 aPaugam-Burtz, C  uhttps://www.notifylibrary.org/reference/738