02253nas a2200265   4500008003900000245014900039210006900188260000800257300001200265490000700277520147600284100001501760700001501775700001501790700001401805700001501819700001501834700001501849700001401864700001401878700001501892700001601907700001601923856004801939       2009                          d00aShort and long-term safety of lenograstim administration in healthy peripheral haematopoietic progenitor cell donors: a single centre experience0 aShort and longterm safety of lenograstim administration in healt  cAug  a163 - 80 v443 aHealthy donors (HDs) who were mobilized using lenograstim (LENO) and who were undergoing peripheral haematopoietic progenitor cell collection with apheresis (HPC-A) were enrolled in a surveillance protocol. In all, 184 HDs have been assessed with a median follow-up of 62 months (range 2-155). HDs received LENO at a median dose of 10 microg/kg (range 5-15). Bone pain was reported as the most frequent short-term adverse event (71.2%). Other commonly observed short-term symptoms included fatigue (19.0%), fever (5.4%), headache (27.7%), nausea (12.0%) and insomnia (22.3%). Spleen size increased in 4.3% of the donors. No vascular disorders or cardiac disease occurred. Long-term follow-up included monitoring of adverse events, neoplastic disease or other pathologies. Transit ischaemic attack occurred in one donor (39 months post-donation). One autoimmune event was reported at 28 months post-recombinant human granulocyte (rhG)-CSF (ankylosing spondylitis); one donor with a history of chronic obstructive pulmonary disease developed secondary polyglobulia (50 months post-rhG-CSF). One donor was diagnosed with lung cancer at 19 months post-donation. No haematological disease was observed. In conclusion, the short-term safety appears to be verified, whereas, although the study identified no increased risks of malignancy among HDs who received rhG-CSF, long-term safety requires more complete data sets, especially a longer follow-up and a larger number of HDs.1 aMartino, M1 aConsole, G1 aDattola, A1 aCallea, I1 aMessina, G1 aMoscato, T1 aMassara, E1 aIrrera, G1 aFedele, R1 aGervasi, A1 aBresolin, G1 aIacopino, P  uhttps://www.notifylibrary.org/reference/969