02470nas a2200313 4500008004100000245010300041210006900144520160900213100001601822700001301838700001901851700001501870700001401885700001401899700001701913700001401930700001901944700001301963700001201976700001301988700001602001700001402017700001302031700001602044700001502060700001802075700001402093856004902107 2010 eng d00aDonor Derived Bacterial Infections: Report From the Disease Transmission Advisory Committee (DTAC)0 aDonor Derived Bacterial Infections Report From the Disease Trans3 a

Background: Donor derived bacterial infections (DDBI) are an uncommon but serious complication of organ transplantation, potentially resulting in allograft loss & patient death.

Methods: The DTAC database was reviewed for cases of potential DDBI reported from 2006 to 2009. Cases were analyzed for bacterial pathogen, culture site & risk for infection, organs transplanted, antimicrobials, as well as allograft and patient outcomes. Mycobacterial infections were excluded from this analysis.

Results: 38 cases of potential DDBI were reported to DTAC. 14 cases of infection resulted in 25 recipients with transmitted DDBI. 2 donors with Ehrlichia resulted in 2/3 recipient transmission; all survived. 1 case of Legionella possibly transmitted infection to 1/6 recipients (lung only). 11 donors with pyogenic bacteria transmitted infections to 22 recipients (see Table 1); none of the affected recipients received appropriate antibiotic prophylaxis. 8 recipients expired, 2 others lost grafts; mycotic aneurysms, were common, especially with Gram negative infection. There were 16 donors with bacterial infections that did not result in transmission to 34 recipients (including 6 from pyogenic bacteria, 6 with syphilis) following receipt of appropriate antibiotics.

Conclusion: DDBI can be a significant cause of morbidity and mortality in organ transplant recipients, especially when grossly contaminated organs used or in the absence of prompt administration of appropriate prophylactic antimicrobials.

1 aBlumberg, E1 aGreen, M1 aCovington, S G1 aTaranto, S1 aTaylor, K1 aParker, K1 aChin-Hong, P1 aDiMaio, M1 aGockerman, J P1 aGreen, M1 aHasz, R1 aKubak, B1 aLebovitz, D1 aPruett, T1 aSmith, A1 aTeperman, L1 aVasudev, B1 aNalesnik, M A1 aIson, M G uhttps://www.notifylibrary.org/reference/1838