07128nas a2200517   4500008004500000022001400045245012400059210006900183260001000252300000600262490000700268520578500275653002206060653003206082100001306114700001806127700001306145700001406158700001506172700001306187700001206200700001506212700001706227700001406244700001706258700001206275700001506287700001806302700001206320700001406332700001506346700001506361700001706376700001206393700001406405700001606419700001906435700001306454700001906467700001806486700001606504700001306520700001306533700001506546856004906561       2010                        Engldsh    a1058-483800aManagement and Outcomes after Multiple Corneal and Solid Organ Transplantations from a Donor Infected with Rabies Virus0 aManagement and Outcomes after Multiple Corneal and Solid Organ T  c42095  a20 v503 aBackground. This article describes multiple transmissions of rabies via transplanted solid organ from a single infected donor. The empirical Milwaukee treatment regimen was used in the recipients. Methods. Symptomatic patients were treated by deep sedation (ketamine, midazolam, and phenobarbital), ribavirin, interferon, and active and passive vaccination. Viral loads and antibodies were continuously monitored. Results. Recipients of both cornea and liver transplants developed no symptoms. The recipient of the liver transplant had been vaccinated [reversed tilde]20 years before transplantation. Two recipients of kidney and lung transplants developed rabies and died within days of symptomatic disease. Another kidney recipient was treated 7 weeks before he died. The cerebrospinal fluid viral load remained at constant low levels (<10,000 copies/mL) for [reversed tilde]5 weeks; it increased suddenly by almost 5 orders of magnitude thereafter. After death, no virus was found in peripheral compartments (nerve tissue, heart, liver, or the small intestine) in this patient, in contrast to in patients in the same cohort who died early. Conclusions. 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Trans R Soc Trop Med Hyg 2008; 102:979-982.10aClinical Medicine10aLife & Biomedical Sciences.1 aMaier, T1 aSchwarting, A1 aMauer, D1 aRoss, R S1 aMartens, A1 aKliem, V1 aWahl, J1 aPanning, M1 aBaumgarte, S1 aMuller, T1 aPfefferle, S1 aEbel, H1 aSchmidt, J1 aTennerRacz, K1 aRacz, P1 aSchmid, M1 aStruber, M1 aWolters, B1 aGotthardt, D1 aBitz, F1 aFrisch, L1 aPfeiffer, N1 aFickenscher, H1 aSauer, P1 aRupprecht, C E1 aRoggendorf, M1 aHaverich, A1 aGalle, P1 aHoyer, J1 aDrosten, C  uhttps://www.notifylibrary.org/reference/1814